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1
Keys to Amyloid City: Computation and NMR Reveal Potential TDP-43 ALS Intermediates.通往淀粉样蛋白之城的钥匙:计算与核磁共振揭示潜在的TDP - 43肌萎缩侧索硬化症中间体
Biophys J. 2018 Nov 6;115(9):1625-1627. doi: 10.1016/j.bpj.2018.09.012. Epub 2018 Sep 22.
2
Aberrant assembly of RNA recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein of 43 kDa (TDP-43).RNA 识别基序 1 的异常组装与 43 kDa T 细胞受体 DNA 结合蛋白(TDP-43)的致病性转化有关。
J Biol Chem. 2013 May 24;288(21):14886-905. doi: 10.1074/jbc.M113.451849. Epub 2013 Apr 4.
3
Inclusions in frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP) and amyotrophic lateral sclerosis (ALS), but not FTLD with FUS proteinopathy (FTLD-FUS), have properties of amyloid.在伴有TDP-43蛋白病的额颞叶痴呆(FTLD-TDP)和肌萎缩侧索硬化症(ALS)中出现的包涵体具有淀粉样蛋白的特性,但在伴有FUS蛋白病的额颞叶痴呆(FTLD-FUS)中则不然。
Acta Neuropathol. 2013 Mar;125(3):463-5. doi: 10.1007/s00401-013-1089-6. Epub 2013 Feb 3.
4
The amyloidogenicity of a C-terminal region of TDP-43 implicated in Amyotrophic Lateral Sclerosis can be affected by anions, acetylation and homodimerization.TDP-43 蛋白 C 端区域与肌萎缩性侧索硬化症有关,其淀粉样变性可以受到阴离子、乙酰化和同源二聚化的影响。
Biochimie. 2018 Jul;150:76-87. doi: 10.1016/j.biochi.2018.05.003. Epub 2018 May 8.
5
TDP-43 skeins show properties of amyloid in a subset of ALS cases.TDP-43 纤维在一部分 ALS 病例中表现出淀粉样蛋白的特性。
Acta Neuropathol. 2013 Jan;125(1):121-31. doi: 10.1007/s00401-012-1055-8. Epub 2012 Nov 3.
6
ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43.导致肌萎缩侧索硬化症的突变显著扰乱了TDP-43内在无序的朊病毒样结构域的自组装及其与核酸的相互作用。
PLoS Biol. 2016 Jan 6;14(1):e1002338. doi: 10.1371/journal.pbio.1002338. eCollection 2016 Jan.
7
Intracellular Conformation of Amyotrophic Lateral Sclerosis-Causative TDP-43.肌萎缩性侧索硬化症致病蛋白 TDP-43 的细胞内构象
Int J Mol Sci. 2023 Mar 14;24(6):5513. doi: 10.3390/ijms24065513.
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TDP-43 in amyotrophic lateral sclerosis - is it a prion disease?肌萎缩侧索硬化症中的TDP-43——它是一种朊病毒病吗?
Eur J Neurol. 2015 May;22(5):753-61. doi: 10.1111/ene.12706.
9
Possible concurrence of TDP-43, tau and other proteins in amyotrophic lateral sclerosis/frontotemporal lobar degeneration.肌萎缩侧索硬化症/额颞叶痴呆中TDP-43、tau蛋白及其他蛋白可能同时存在的情况。
Neuropathology. 2018 Feb;38(1):72-81. doi: 10.1111/neup.12428. Epub 2017 Sep 27.
10
Characterizing TDP-43 Oligomeric Assembly: Mechanistic and Structural Implications Involved in the Etiology of Amyotrophic Lateral Sclerosis.描述 TDP-43 低聚物组装:肌萎缩性侧索硬化症发病机制中的机制和结构意义。
ACS Chem Neurosci. 2019 Sep 18;10(9):4112-4123. doi: 10.1021/acschemneuro.9b00337. Epub 2019 Sep 3.

本文引用的文献

1
Characterization of TDP-43 RRM2 Partially Folded States and Their Significance to ALS Pathogenesis.TDP-43 RRM2 部分折叠状态的特征及其对 ALS 发病机制的意义。
Biophys J. 2018 Nov 6;115(9):1673-1680. doi: 10.1016/j.bpj.2018.09.011. Epub 2018 Sep 21.
2
Comparative analysis of thermal unfolding simulations of RNA recognition motifs (RRMs) of TAR DNA-binding protein 43 (TDP-43).TDP-43 蛋白 RNA 识别基序(RRMs)热变性模拟的比较分析。
J Biomol Struct Dyn. 2019 Jan;37(1):178-194. doi: 10.1080/07391102.2017.1422026. Epub 2018 Jan 10.
3
Mutation in the RRM2 domain of TDP-43 in Amyotrophic Lateral Sclerosis with rapid progression associated with ubiquitin positive aggregates in cultured motor neurons.快速进展型肌萎缩侧索硬化症中TDP - 43的RRM2结构域突变与培养的运动神经元中泛素阳性聚集体相关。
Amyotroph Lateral Scler Frontotemporal Degener. 2018 Feb;19(1-2):149-151. doi: 10.1080/21678421.2017.1349152. Epub 2017 Jul 13.
4
Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade.蛋白质错误折叠、淀粉样纤维形成与人类疾病:过去十年研究进展综述。
Annu Rev Biochem. 2017 Jun 20;86:27-68. doi: 10.1146/annurev-biochem-061516-045115. Epub 2017 May 12.
5
ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43.导致肌萎缩侧索硬化症的突变显著扰乱了TDP-43内在无序的朊病毒样结构域的自组装及其与核酸的相互作用。
PLoS Biol. 2016 Jan 6;14(1):e1002338. doi: 10.1371/journal.pbio.1002338. eCollection 2016 Jan.
6
Replica-Averaged Metadynamics.复制品平均元动力学
J Chem Theory Comput. 2013 Dec 10;9(12):5610-7. doi: 10.1021/ct4006272. Epub 2013 Nov 21.
7
Folding of the RNA recognition motif (RRM) domains of the amyotrophic lateral sclerosis (ALS)-linked protein TDP-43 reveals an intermediate state.RNA 识别基序(RRM)结构域的折叠揭示了肌萎缩侧索硬化症(ALS)相关蛋白 TDP-43 的中间状态。
J Biol Chem. 2014 Mar 21;289(12):8264-76. doi: 10.1074/jbc.M113.542779. Epub 2014 Feb 4.
8
The truncated C-terminal RNA recognition motif of TDP-43 protein plays a key role in forming proteinaceous aggregates.TDP-43 蛋白的截短 C 端 RNA 识别基序在形成蛋白聚集物中起关键作用。
J Biol Chem. 2013 Mar 29;288(13):9049-57. doi: 10.1074/jbc.M112.438564. Epub 2013 Jan 31.
9
Structural insights into TDP-43 in nucleic-acid binding and domain interactions.TDP-43在核酸结合和结构域相互作用方面的结构见解。
Nucleic Acids Res. 2009 Apr;37(6):1799-808. doi: 10.1093/nar/gkp013. Epub 2009 Jan 27.
10
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.额颞叶痴呆和肌萎缩侧索硬化症中泛素化的TDP-43
Science. 2006 Oct 6;314(5796):130-3. doi: 10.1126/science.1134108.

Keys to Amyloid City: Computation and NMR Reveal Potential TDP-43 ALS Intermediates.

作者信息

Babinchak W Michael, Li Zhenlu, Buck Matthias

机构信息

Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio.

Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio.

出版信息

Biophys J. 2018 Nov 6;115(9):1625-1627. doi: 10.1016/j.bpj.2018.09.012. Epub 2018 Sep 22.

DOI:10.1016/j.bpj.2018.09.012
PMID:30290957
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6225042/
Abstract
摘要