Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Department of Neurology, Utano National Hospital, National Hospital Organization, 8 Ondoyama-Cho, Narutaki, Ukyoku, Kyoto 616-8255, Japan.
J Neuroimmunol. 2018 Dec 15;325:69-73. doi: 10.1016/j.jneuroim.2018.09.011. Epub 2018 Sep 27.
This meta-analysis aimed to systematically review current literature measuring the thickness of retinal nerve fiber layer (RNFL) in patients with myelin oligodendrocyte glycoprotein antibodies (MOG-ab) associated optic neuritis. Ten studies were enrolled and the results showed that the degree of RNFL loss in MOG-ab-positive optic neuritis patients may not differ from that of AQP4-ab patients. However, patients who were positive for MOG-ab showed more severe RNFL loss than those who were seronegative.
本荟萃分析旨在系统回顾目前测量髓鞘少突胶质细胞糖蛋白抗体（MOG-ab）相关视神经炎患者视网膜神经纤维层（RNFL）厚度的文献。纳入了 10 项研究，结果表明 MOG-ab 阳性视神经炎患者的 RNFL 丧失程度可能与 AQP4-ab 患者无差异。然而，MOG-ab 阳性患者的 RNFL 丧失程度比血清阴性患者更严重。
