Zhou Lin, Tan Xiao, Wang Ling, Zhao Xiujuan, Qiu Wei, Yang Hui
Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, China.
Shenzhen Aier Eye Hospital Affiliated to Jinan University, Shenzhen, Guangdong 518032, China.
J Ophthalmol. 2022 Mar 22;2022:4951491. doi: 10.1155/2022/4951491. eCollection 2022.
In this study, the aim is to compare the recovery pattern among patients with acute myelin oligodendrocyte glycoprotein antibody-seropositive optic neuritis (MOG-Ab + ON) attacks and aquaporin-4 antibody-seropositive ON (AQP4-Ab + ON) or -seronegative ON. At the onset of the first-ever ON attack, the thickness of RNFL (RNFLt) in the MOG-Ab + ON group was significantly thicker than others ( < 0.05), while visual function damage was not significantly different to other groups. One month to six months after onset, the MOG-Ab + ON group showed significantly better visual function ( < 0.05) than the other two groups, while the RNFLt showed no significant difference among the three groups ( > 0.05). MOG-Ab + ON and AQP4-Ab + ON groups showed rapid recovery in the first month and then plateaued. The annual relapse rate was significantly higher in MOG-Ab + ON and AQP4-Ab + ON groups than seronegative ON. The relapse interval of the MOG-Ab + ON group (9.00 ± 7.86 months) was significantly shorter than that of the AQP4-Ab + ON group (45.76 ± 37.82 months) ( < 0.05) but showed no significant difference from that of the seronegative ON group ( > 0.05). To sum up, the recovery patterns were different among these three types of ON. RNFLt was not parallel to the recovery of visual function among these types of ON. MOG-Ab + ON had the mildest visual function damage but the most substantial RNFL changes, while AQP4-Ab + ON suffered the worst function damage. MOG-Ab + ON had a similar relapse rate as AQP4-Ab + ON but a shorter interval, indicating that relapse prevention was necessary and should be initiated as early as possible.
在本研究中，目的是比较急性髓鞘少突胶质细胞糖蛋白抗体血清阳性视神经炎（MOG-Ab+ON）发作患者与水通道蛋白4抗体血清阳性ON（AQP4-Ab+ON）或血清阴性ON患者的恢复模式。在首次ON发作开始时，MOG-Ab+ON组的视网膜神经纤维层厚度（RNFLt）明显厚于其他组（<0.05），而视觉功能损害与其他组无显著差异。发作后1个月至6个月，MOG-Ab+ON组的视觉功能明显优于其他两组（<0.05），而三组之间的RNFLt无显著差异（>0.05）。MOG-Ab+ON组和AQP4-Ab+ON组在第一个月显示快速恢复，然后趋于平稳。MOG-Ab+ON组和AQP4-Ab+ON组的年复发率明显高于血清阴性ON组。MOG-Ab+ON组的复发间隔（9.00±7.86个月）明显短于AQP4-Ab+ON组（45.76±37.82个月）（<0.05），但与血清阴性ON组无显著差异（>0.05）。综上所述，这三种类型的ON恢复模式不同。在这些类型的ON中，RNFLt与视觉功能的恢复不平行。MOG-Ab+ON的视觉功能损害最轻，但RNFL变化最大，而AQP4-Ab+ON的功能损害最严重。MOG-Ab+ON的复发率与AQP4-Ab+ON相似，但间隔较短，表明预防复发是必要的，应尽早开始。
