Department of Biological Science and Technology, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, China
Department of Biological Science and Technology, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, China.
Biosci Rep. 2018 Nov 15;38(6). doi: 10.1042/BSR20180853. Print 2018 Dec 21.
How single nucleotide polymorphisms in long non-coding RNAs are involved in cancer susceptibility remains poorly understood. We hypothesized that polymerase II polypeptide E () rs3787016 polymorphism, identified in a genome-wide association study of prostate cancer, might be a common genetic risk factor for cancer risk. To address this issue, we here conducted a case-control study to investigate the association of rs3787016 polymorphism with risk of liver and lung cancer (including 800 normal controls, 480 liver cancer patients, and 550 lung cancer patients), followed by a meta-analysis. The genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism and confirmed by sequencing. Although no significant association was found for rs3787016 with risk of liver or lung cancer, the further stratified analysis identified that rs3787016 contributed to liver cancer risk particularly for over than 60 years individuals who drink. Moreover, the meta-analysis demonstrated that rs3787016 was associated with overall cancer risk and prostate cancer risk. Collectively, the rs3787016 polymorphism may be a valuable biomarker for cancer predisposition.
长非编码 RNA 中的单核苷酸多态性如何参与癌症易感性仍知之甚少。我们假设在前列腺癌全基因组关联研究中发现的聚合酶 II 多肽 E()rs3787016 多态性可能是癌症风险的常见遗传危险因素。为了解决这个问题，我们进行了一项病例对照研究，调查 rs3787016 多态性与肝癌和肺癌风险（包括 800 名正常对照、480 名肝癌患者和 550 名肺癌患者）之间的关联，随后进行了荟萃分析。通过聚合酶链反应-限制性片段长度多态性进行基因分型，并通过测序进行确认。尽管 rs3787016 与肝癌或肺癌风险之间没有显著关联，但进一步的分层分析表明，rs3787016 特别与 60 岁以上饮酒的人群的肝癌风险有关。此外，荟萃分析表明 rs3787016 与总体癌症风险和前列腺癌风险相关。总之，rs3787016 多态性可能是癌症易感性的有价值的生物标志物。
