Chu Haiyan, Chen Yaoyao, Yuan Qinbo, Hua Qiuhan, Zhang Xu, Wang Meilin, Tong Na, Zhang Wei, Chen Jinfei, Zhang Zhengdong
Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China.
Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China.
Oncotarget. 2017 Jun 27;8(26):43271-43283. doi: 10.18632/oncotarget.14920.
Long non-coding RNAs (LncRNAs) have been widely studied and aberrant expression of lncRNAs are involved in diverse cancers. Genetic variation in lncRNAs can influence the lncRNAs expression and function. At present, there are many studies to investigate the association between lncRNAs polymorphisms and cancer susceptibility. However, it has no systematic study to evaluate the association. We performed a meta-analysis to summarize the results of common lncRNAs (HOTAIR, PRNCR1, POLR2E and H19) polymorphisms on cancer risk, by using the random-effect model to obtain the odds ratio (ORs) and 95% confidence interval (95%CI). We also applied the meta-regression and publication bias analysis to seek the source of heterogeneity and evaluate the stability of results, respectively. The summary results indicated that HOTAIR rs920778 increased the cancer risk in recessive model (OR = 1.61, 95% CI = 1.08-2.41, Pheterogeneity<0.001). For PRNCR1 (rs1016343, rs16901946) and POLR2E (rs3787016), we also found the significant association with incresed risk of cancer (all P<0.05). However, we did not observe any significant association between H19 rs2107425 and cancer risk. Our meta-analysis results revealed that these four lncRNAs polymorphisms (HOTAIR rs920778, PRNCR1 rs1016343 and rs16901946, POLR2E rs3787016) can contribute to cancer risk. Further studies should confirm these findings.
长链非编码RNA（LncRNAs）已得到广泛研究，lncRNAs的异常表达与多种癌症相关。lncRNAs的基因变异可影响其表达和功能。目前，有许多研究探讨lncRNAs多态性与癌症易感性之间的关联。然而，尚无系统研究来评估这种关联。我们进行了一项荟萃分析，以总结常见lncRNAs（HOTAIR、PRNCR1、POLR2E和H19）多态性对癌症风险的影响，采用随机效应模型获得比值比（ORs）和95%置信区间（95%CI）。我们还应用荟萃回归和发表偏倚分析，分别寻找异质性来源并评估结果的稳定性。汇总结果表明，HOTAIR rs920778在隐性模型中增加了癌症风险（OR = 1.61，95%CI = 1.08 - 2.41，P异质性<0.001）。对于PRNCR1（rs1016343，rs16901946）和POLR2E（rs3787016），我们也发现与癌症风险增加存在显著关联（所有P<0.05）。然而，我们未观察到H19 rs2107425与癌症风险之间存在任何显著关联。我们的荟萃分析结果显示，这四种lncRNAs多态性（HOTAIR rs920778、PRNCR1 rs1016343和rs16901946、POLR2E rs3787016）可能与癌症风险相关。进一步的研究应证实这些发现。
