• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Genome-wide association study identifies an acute myeloid leukemia susceptibility locus near BICRA.

作者信息

Walker Christopher J, Oakes Christopher C, Genutis Luke K, Giacopelli Brian, Liyanarachchi Sandya, Nicolet Deedra, Eisfeld Ann-Kathrin, Scholz Markus, Brock Pamela, Kohlschmidt Jessica, Mrózek Krzysztof, Bill Marius, Carroll Andrew J, Kolitz Jonathan E, Powell Bayard L, Wang Eunice S, Niederwieser Dietger W, Stone Richard M, Byrd John C, Schwind Sebastian, de la Chapelle Albert, Bloomfield Clara D

机构信息

The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.

Alliance Statistics and Data Center, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.

出版信息

Leukemia. 2019 Mar;33(3):771-775. doi: 10.1038/s41375-018-0281-z. Epub 2018 Oct 5.

DOI:10.1038/s41375-018-0281-z
PMID:30291333
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6405293/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de70/6405293/18523cdbcef5/nihms-1506653-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de70/6405293/18523cdbcef5/nihms-1506653-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de70/6405293/18523cdbcef5/nihms-1506653-f0001.jpg

相似文献

1
Genome-wide association study identifies an acute myeloid leukemia susceptibility locus near BICRA.全基因组关联研究确定了BICRA附近的一个急性髓系白血病易感位点。
Leukemia. 2019 Mar;33(3):771-775. doi: 10.1038/s41375-018-0281-z. Epub 2018 Oct 5.
2
Genome-wide association study identifies susceptibility loci for acute myeloid leukemia.全基因组关联研究鉴定出急性髓细胞白血病的易感性位点。
Nat Commun. 2021 Oct 29;12(1):6233. doi: 10.1038/s41467-021-26551-x.
3
Integrating expression-related SNPs into genome-wide gene- and pathway-based analyses identified novel lung cancer susceptibility genes.将表达相关的 SNPs 整合到全基因组基因和通路的基于分析的研究中，鉴定了新的肺癌易感基因。
Int J Cancer. 2018 Apr 15;142(8):1602-1610. doi: 10.1002/ijc.31182. Epub 2017 Dec 12.
4
Identification of a novel susceptibility locus at 16q23.1 associated with childhood acute lymphoblastic leukemia in Han Chinese.在中国汉族人群中，鉴定出一个与儿童急性淋巴细胞白血病相关的位于16q23.1的新的易感基因座。
Hum Mol Genet. 2016 Jul 1;25(13):2873-2880. doi: 10.1093/hmg/ddw112. Epub 2016 Apr 19.
5
Genome-wide association study of rheumatoid arthritis in Koreans: population-specific loci as well as overlap with European susceptibility loci.韩国人类风湿关节炎的全基因组关联研究：特定人群位点以及与欧洲易感位点的重叠。
Arthritis Rheum. 2011 Apr;63(4):884-93. doi: 10.1002/art.30235.
6
Fine mapping of 2q35 high-risk neuroblastoma locus reveals independent functional risk variants and suggests full-length BARD1 as tumor-suppressor.2q35 高危神经母细胞瘤区域的精细定位揭示了独立的功能风险变异体，并提示全长 BARD1 为肿瘤抑制基因。
Int J Cancer. 2018 Dec 1;143(11):2828-2837. doi: 10.1002/ijc.31822. Epub 2018 Oct 4.
7
Common predisposition alleles for moderately common cancers: bladder cancer.常见的中度常见癌症易患基因：膀胱癌。
Curr Opin Genet Dev. 2010 Jun;20(3):218-24. doi: 10.1016/j.gde.2010.01.002. Epub 2010 Feb 12.
8
Suggestion of roles for both common and rare risk variants in genome-wide studies of schizophrenia.精神分裂症全基因组研究中常见和罕见风险变异的作用提示
Arch Gen Psychiatry. 2010 Jul;67(7):667-73. doi: 10.1001/archgenpsychiatry.2010.69.
9
Dissection of the Major Hematopoietic Quantitative Trait Locus in Chromosome 6q23.3 Identifies miR-3662 as a Player in Hematopoiesis and Acute Myeloid Leukemia.对6号染色体6q23.3上主要造血数量性状位点的剖析确定miR-3662在造血和急性髓系白血病中发挥作用。
Cancer Discov. 2016 Sep;6(9):1036-51. doi: 10.1158/2159-8290.CD-16-0023. Epub 2016 Jun 27.
10
Identification of five novel genetic loci related to facial morphology by genome-wide association studies.全基因组关联研究鉴定与面部形态相关的五个新的遗传位点。
BMC Genomics. 2018 Jun 19;19(1):481. doi: 10.1186/s12864-018-4865-9.

引用本文的文献

1
Replication of a GWAS signal near with AML using a disease-only cohort and external population-based controls.使用仅患有疾病的队列和基于外部人群的对照，在与急性髓系白血病相关的区域复制全基因组关联研究信号。
Blood Neoplasia. 2025 May 19;2(3):100118. doi: 10.1016/j.bneo.2025.100118. eCollection 2025 Aug.
2
Cytarabine Pharmacogenomics and Outcomes Among Children and Young Adults With Acute Myeloid Leukemia.阿糖胞苷的药物基因组学与急性髓系白血病儿童及青年患者的预后
JAMA Netw Open. 2025 Jun 2;8(6):e2516296. doi: 10.1001/jamanetworkopen.2025.16296.
3
Multiomic profiling identifies predictors of survival in African American patients with acute myeloid leukemia.

本文引用的文献

1
Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.全基因组单倍型关联研究确定FGFR2基因为急性髓系白血病的风险基因。
Oncotarget. 2017 Jan 31;8(5):7891-7899. doi: 10.18632/oncotarget.13631.
多组学分析鉴定出非裔美国人急性髓系白血病患者生存的预测因子。
Nat Genet. 2024 Nov;56(11):2434-2446. doi: 10.1038/s41588-024-01929-x. Epub 2024 Oct 4.
4
Inherited blood cancer predisposition through altered transcription elongation.通过改变转录延伸导致遗传性血液癌易感性。
Cell. 2024 Feb 1;187(3):642-658.e19. doi: 10.1016/j.cell.2023.12.016. Epub 2024 Jan 12.
5
Current Landscape of Genome-Wide Association Studies in Acute Myeloid Leukemia: A Review.急性髓系白血病全基因组关联研究的现状：综述
Cancers (Basel). 2023 Jul 12;15(14):3583. doi: 10.3390/cancers15143583.
6
Germline SNPs previously implicated as prognostic biomarkers do not associate with outcomes in intensively treated AML.先前被认为是预后生物标志物的种系单核苷酸多态性（germline SNPs）与接受强化治疗的急性髓系白血病（AML）患者的预后无关。
Blood Adv. 2023 Mar 28;7(6):1040-1044. doi: 10.1182/bloodadvances.2022007988.
7
Cohort Profile: The LIFE-Adult-Study.队列简介：LIFE成人研究。
Int J Epidemiol. 2023 Feb 8;52(1):e66-e79. doi: 10.1093/ije/dyac114.
8
Genome-wide association study identifies susceptibility loci for acute myeloid leukemia.全基因组关联研究鉴定出急性髓细胞白血病的易感性位点。
Nat Commun. 2021 Oct 29;12(1):6233. doi: 10.1038/s41467-021-26551-x.
9
Genome-Wide Association Analyses Identify Variants in Associated With Acute Myeloid Leukemia and Myelodysplastic Syndrome Susceptibility.全基因组关联分析确定与急性髓系白血病和骨髓增生异常综合征易感性相关的变异。
Front Genet. 2021 Jun 17;12:554948. doi: 10.3389/fgene.2021.554948. eCollection 2021.
10
Gene expression signature predicts relapse in adult patients with cytogenetically normal acute myeloid leukemia.基因表达特征可预测细胞遗传学正常的成人急性髓系白血病患者的复发。
Blood Adv. 2021 Mar 9;5(5):1474-1482. doi: 10.1182/bloodadvances.2020003727.