Center for Interventional Pain and Spine, Wilmington, DE, USA.
Curr Pain Headache Rep. 2018 Oct 5;22(12):83. doi: 10.1007/s11916-018-0732-2.
The purpose of this review is to evaluate and explain our current understanding of the clinical use of buprenorphine in the treatment of chronic pain.
There has been few high-quality, unbiased studies performed on the use of buprenorphine in the treatment of chronic pain. Buprenorphine is an effective and safe analgesic that is tolerated at least as well, if not better, than other opioids. Given its safety and mechanistic advantages, the authors believe there is an important role for buprenorphine in the treatment of chronic pain severe enough to warrant the use of an opioid analgesic. Though data is lacking for superiority in chronic pain states, the other advantages of the molecule make it the preferential first-line opioid for around-the-clock pain in our practice.
本综述旨在评估和解释我们目前对丁丙诺啡在慢性疼痛治疗中的临床应用的理解。
很少有高质量、无偏见的研究针对丁丙诺啡在慢性疼痛治疗中的应用进行。丁丙诺啡是一种有效且安全的镇痛药，其耐受性至少与其他阿片类药物一样好，如果不是更好的话。鉴于其安全性和机制优势，作者认为丁丙诺啡在治疗疼痛剧烈需要使用阿片类镇痛药的慢性疼痛方面具有重要作用。虽然在慢性疼痛状态下缺乏优越性的数据，但该分子的其他优势使其成为我们实践中治疗全天候疼痛的首选一线阿片类药物。
