Institute of Island and Coastal Ecosystems, Ocean College, Zhejiang University, Zhoushan 316021, China; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne 3004, Australia.
Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne 3004, Australia.
Environ Int. 2018 Dec;121(Pt 1):515-522. doi: 10.1016/j.envint.2018.09.033. Epub 2018 Oct 3.
Limited evidence is available on the health effects of particulate matter with an aerodynamic diameter of <1 μm (PM), mainly due to the lack of its ground measurement worldwide.
To identify and examine the mortality risks and mortality burdens associated with PM, PM, and PM in Zhejiang province, China.
We collected daily data regarding all-cause (stratified by age and gender), cardiovascular, stroke, respiratory, and chronic obstructive pulmonary disease (COPD) mortality, and PM, PM, and PM, from 11 cities in Zhejiang province, China during 2013 and 2017. We used a quasi-Poisson regression model to estimate city-specific associations between mortality and PM concentrations. Then we used a random-effect meta-analysis to pool the provincial estimates. To show the mortality burdens of PM, PM, and PM, we calculated the mortality fractions and deaths attributable to these PMs.
Daily concentrations of PM, PM, and PM ranged between 0-199 μg/m, 0-218 μg/m, and 0-254 μg/m, respectively; Mortality effects were significant in lag 0-2 days. The relative risks for all-cause mortality were 1.0064 (95% CI: 1.0034, 1.0094), 1.0061 (95% CI: 1.0034, 1.0089), and 1.0060 (95% CI: 1.0038, 1.0083) associated with a 10 μg/m increase in PM, PM and PM, respectively. Age- and gender-stratified analysis shows that elderly people (aged 65+) and females are more sensitive to PMs. The mortality fractions of all-cause mortality were estimated to be 2.39% (95% CI: 1.28, 3.48) attributable to PM, 2.53% (95% CI: 1.42, 3.63) attributable to PM, and 3.08% (95% CI: 1.95, 4.19) attributable to PM. The ratios of attributable cause-specific deaths for PM/PM, PM/PM, and PM/PM were higher than the ratios of their respective concentrations.
PM, PM and PM are risk factors of all-cause, cardiovascular, stroke, respiratory, and COPD mortality. PM accounts for the vast majority of short-term PM- and PM-induced mortality. Our analyses support the notion that smaller size fractions of PM have a more toxic mortality impacts, which suggests to develop strategies to prevent and control PM in China, such as to foster strict regulations for automobile and industrial emissions.
由于全球范围内缺乏地面测量数据,目前有关 <1μm 空气动力学直径的颗粒物(PM)对健康影响的证据有限。
确定并研究中国浙江省 PM、PM 和 PM 与死亡率之间的关联及其导致的死亡负担。
我们收集了 2013 年至 2017 年期间中国浙江省 11 个城市的全因死亡率(按年龄和性别分层)、心血管疾病死亡率、中风死亡率、呼吸疾病死亡率和慢性阻塞性肺疾病(COPD)死亡率,以及 PM、PM 和 PM 浓度数据。我们使用拟泊松回归模型估计死亡率与 PM 浓度之间的城市特异性关联。然后,我们使用随机效应荟萃分析来汇总省级估计值。为了展示 PM、PM 和 PM 的死亡负担,我们计算了这些 PM 导致的死亡率分数和归因于这些 PM 的死亡人数。
PM、PM 和 PM 的日浓度范围分别为 0-199μg/m、0-218μg/m 和 0-254μg/m;滞后 0-2 天的死亡率效应显著。与 PM 浓度每增加 10μg/m 相关的全因死亡率的相对风险分别为 1.0064(95%CI:1.0034,1.0094)、1.0061(95%CI:1.0034,1.0089)和 1.0060(95%CI:1.0038,1.0083)。年龄和性别分层分析表明,老年人(65 岁以上)和女性对 PM 更为敏感。全因死亡率的死亡率分数估计为 2.39%(95%CI:1.28,3.48)归因于 PM、2.53%(95%CI:1.42,3.63)归因于 PM 和 3.08%(95%CI:1.95,4.19)归因于 PM。PM/PM、PM/PM 和 PM/PM 的归因于特定原因的死亡比例高于其各自浓度的比例。
PM、PM 和 PM 是全因、心血管疾病、中风、呼吸和 COPD 死亡的危险因素。PM 导致了大部分由 PM 和 PM 引起的短期死亡。我们的分析支持这样一种观点,即 PM 更小的粒径分数具有更大的毒性致死影响,这表明中国需要制定预防和控制 PM 的策略,例如加强对汽车和工业排放的监管。