Bursztyn P G, King M H
J Hypertens. 1986 Dec;4(6):699-702. doi: 10.1097/00004872-198612000-00003.
It has been suggested that dietary linoleic and gamma-linolenic acid may be hypotensive. Fat enriched diets increase blood pressure, and the effects of linoleic and linolenic acids on this increase have been investigated. After a control period on a low fat diet, rabbits were given four fat enriched diets containing different proportions of linoleic, gamma-linolenic and alpha-linolenic acids for 8 weeks, and returned to the low fat control diet for 3 weeks. Blood pressures were measured non-invasively every day. Blood pressures increased from the 4th week of fat feeding. The blood pressure increase at 8 weeks was 10%, 13%, 15% and 14% respectively for primrose, starflower, safflower and olive oils (all P less than 0.001). Return to the low fat control diet for 3 weeks restored blood pressures to near control values. These results do not support the suggestion that either linoleic or gamma-linolenic acids are effective antihypertensive agents.
有人提出膳食中的亚油酸和γ-亚麻酸可能具有降血压作用。富含脂肪的饮食会使血压升高，人们已经对亚油酸和亚麻酸对这种血压升高的影响进行了研究。在低脂饮食的对照期过后，给兔子喂食四种富含不同比例亚油酸、γ-亚麻酸和α-亚麻酸的高脂饮食，持续8周，然后再恢复低脂对照饮食3周。每天采用无创方式测量血压。从喂食高脂饮食的第4周起血压开始升高。8周时，月见草油、琉璃苣油、红花油和橄榄油引起的血压升高分别为10%、13%、15%和14%（所有P值均小于0.001）。恢复低脂对照饮食3周后，血压恢复到接近对照值。这些结果并不支持亚油酸或γ-亚麻酸是有效的抗高血压药物这一观点。
