LabCorp, Center for Esoteric Testing, Burlington, North Carolina.
Thermo Fisher Scientific, Uppsala, Sweden.
Ann Allergy Asthma Immunol. 2019 Jan;122(1):111-116.e1. doi: 10.1016/j.anai.2018.09.466. Epub 2018 Oct 4.
Measurement of IgE antibody to hazelnut components can aid in the prediction of allergic responses to the food.
To investigate the association between patient demographics (age, location) and patterns of allergic sensitization to hazelnut components across the United States and to investigate the degree of correlation between hazelnut sensitization with sensitization to other tree nuts, peanuts, and their components.
Serum samples from 10,503 individuals with hazelnut extract specific IgE (sIgE) levels of 0.35 kU/L or higher were analyzed for IgE antibodies to Cor a 1, 8, 9, and 14 by ImmunoCAP. A subset of these patients were analyzed for IgE antibodies to peanut, walnut, and cashew nut IgE along with associated components.
Among hazelnut sensitized individuals, children (<3 years old) were predominantly sensitized to Cor a 9 and Cor a 14. Conversely, Cor a 1 sIgE sensitization was much higher in adults than children, especially in the Northeastern United States. Cor a 8 sensitization was relatively constant (near 10%) across all ages. Cosensitization of hazelnut with other tree nuts and peanuts was related to correlation of IgE concentrations of individual component families.
We conclude that sensitization to individual hazelnut components is highly dependent on age and/or geographic location. Component correlations suggest that cosensitization to hazelnut and walnut may be caused by their pathogenesis-related protein 10 allergens, nonspecific lipid transfer proteins, or seed storage proteins, whereas hazelnut and peanut cosensitization is more often caused by cross-reactivity of pathogenesis-related protein 10 (Cor a 1 and Ara h 8) and nonspecific lipid transfer proteins (Cor a 8 and Ara h 9).
测量榛果成分的 IgE 抗体有助于预测对食物的过敏反应。
调查美国各地患者人口统计学特征（年龄、地理位置）与榛果成分过敏致敏模式之间的关联，并研究榛果致敏与其他树坚果、花生及其成分致敏之间的相关性。
分析了 10503 例榛果提取物特异性 IgE（sIgE）水平为 0.35 kU/L 或更高的血清样本，以检测 IgE 抗体对 Cor a 1、8、9 和 14 的反应。对这些患者中的一部分进行了分析，以检测对花生、核桃和腰果 IgE 以及相关成分的 IgE 抗体。
在榛果致敏个体中，儿童（<3 岁）主要对 Cor a 9 和 Cor a 14 致敏。相反，Cor a 1 sIgE 致敏在成人中明显高于儿童，尤其是在美国东北部。Cor a 8 致敏在所有年龄段都相对稳定（接近 10%）。榛果与其他树坚果和花生的共同致敏与个别成分家族 IgE 浓度的相关性有关。
我们得出结论，对个别榛果成分的致敏高度依赖于年龄和/或地理位置。成分相关性表明，榛果和核桃的共同致敏可能是由它们的 10 号发病相关蛋白过敏原、非特异性脂质转移蛋白或种子储存蛋白引起的，而榛果和花生的共同致敏则更常由发病相关蛋白 10（Cor a 1 和 Ara h 8）和非特异性脂质转移蛋白（Cor a 8 和 Ara h 9）的交叉反应引起。
