Gu X, Kang D M, Yin T T, Yang X G, Shao Z J, Tao X R, Qian Y S, Liu K, Hu J
Department of Epidemiology and Health Statistics, School of Public Health and Management, Weifang Medical College, Weifang 261021, China.
Institute of AIDS Prevention and Control, Shandong Provincial Center for Diseases Control and Prevention, Jinan 250014, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2018 Sep 10;39(9):1146-1151. doi: 10.3760/cma.j.issn.0254-6450.2018.09.002.
To analyze the epidemiological characteristics, dynamic trend of development and related influencing factors of hepatitis C in Shandong, China, 2007-2016, also to provide epidemiological evidence for prevention and control of HCV. National surveillance data of hepatitis C from 2007 to 2016 in Shandong was used, with distribution and clustering map of hepatitis C drawn at the county level. Panel Poisson regression was used to explore the influencing factors of hepatitis C at the city level. The incidence of hepatitis C in Shandong increased from 1.49/100 000 in 2007 to 4.72/100 000 in 2016, with the high incidence mainly clustered in the urban regions in Jinan, Zibo, Weihai et al. and surrounding vicinities. Majority of the cases were young adults, with 53.16 (14 711/27 671) of them being farmers. Results from the Multiple panel Poisson regression analysis indicated that factors as: population density (a=1.07, 95: 1.05-1.10), number of hospital per hundred thousand people shared (a=1.16, 95: 1.08-1.24), expenditure of medical fee in rural (a=1.21, 95: 1.08-1.37) and the proportion of the tertiary industry (a=1.08, 95: 1.07-1.09) were all correlated to the incidence of hepatitis C. The incidence of hepatitis C had been increasing rapidly in recent years, in Shandong. Prevention and control of HCV should focus on high risk population. In addition, rural, especially in areas with lower economics provision should be under more attentions, so as to find more concealed cases for early treatment.
分析2007 - 2016年中国山东省丙型肝炎的流行病学特征、发展动态趋势及相关影响因素，为丙型肝炎病毒（HCV）的防控提供流行病学依据。利用山东省2007年至2016年丙型肝炎的国家监测数据，绘制县级丙型肝炎分布和聚集图。采用面板泊松回归分析探讨市级层面丙型肝炎的影响因素。山东省丙型肝炎发病率从2007年的1.49/10万上升至2016年的4.72/10万，高发病率主要集中在济南、淄博、威海等城市地区及其周边。大多数病例为青壮年，其中53.16%（14711/27671）为农民。多面板泊松回归分析结果表明：人口密度（a = 1.07，95%CI：1.05 - 1.10）、每十万人拥有医院数量（a = 1.16，95%CI：1.08 - 1.24）、农村医疗费用支出（a = 1.21，95%CI：1.08 - 1.37）和第三产业比重（a = 1.08，95%CI：1.07 - 1.09）均与丙型肝炎发病率相关。近年来，山东省丙型肝炎发病率呈快速上升趋势。HCV的防控应重点关注高危人群。此外，农村地区，特别是经济条件较差的地区应受到更多关注，以便发现更多隐匿病例进行早期治疗。
