Andriankaja Oelisoa M, Pérez Cynthia M, Modi Ashwin, Suaréz Erick L, Gower Barbara A, Rodríguez Elaine, Joshipura Kaumudi
Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY 40536, USA.
Department of Biostatistics and Epidemiology, Graduate School of Public Health, Medical Sciences Campus, University of Puerto Rico, San Juan 00936-5067, Puerto Rico.
Biomedicines. 2023 May 23;11(6):1507. doi: 10.3390/biomedicines11061507.
The network interaction between systemic inflammatory mediators, endothelial cell adhesion function, and adiponectin as mediators of the association between metabolic diseases and periodontitis has not been evaluated. The objective of this study is to assess whether the interaction of baseline serum levels of TNF-α, hs-CRP, ICAM-1, VCAM-1, and adiponectin leads to periodontitis. Five hundred and ninety-seven overweight/obese (overweight: BMI 25 to <30 kg/m; obese: >30 kg/m) adults, aged 40-65 years, with complete 3-year follow-up data were included. Generalized structural equation models with negative binomial regression were used to estimate the regression coefficient (β) for the outcome number of teeth with probing pocket depth (PPD) ≥ 4 mm and bleeding on probing (BOP) at 3-year follow-up for a 1 standard deviation unit increase (Δ = +1SD) in each biomarker. After adjusting for multiple covariates, baseline ICAM-1 and VCAM-1 had significant direct effects on increased log-transformed number of teeth with PPD ≥ 4 mm and BOP (β: 0.16; 95% CI: 0.02-0.30; β: 0.15; 95% CI: 0.02-0.30, respectively). Baseline hs-CRP showed a significant indirect effect via ICAM-1 on the log-transformed number of teeth with PPD ≥ 4 mm and BOP (β: 4.84; 95% CI: 0.27-9.42). Thus, elevated serum ICAM-1 and VCAM-1 have a significant direct effect and increased hs-CRP has a significant indirect effect on the predicted level of periodontitis at the 3-year follow-up among overweight/obese Hispanic adults.
全身炎症介质、内皮细胞黏附功能以及脂联素作为代谢性疾病与牙周炎关联的介质之间的网络相互作用尚未得到评估。本研究的目的是评估肿瘤坏死因子-α（TNF-α）、高敏C反应蛋白（hs-CRP）、细胞间黏附分子-1（ICAM-1）、血管细胞黏附分子-1（VCAM-1）和脂联素的基线血清水平之间的相互作用是否会导致牙周炎。纳入了597名年龄在40 - 65岁之间的超重/肥胖（超重：体重指数（BMI）25至<30 kg/m；肥胖：>30 kg/m）成年人，他们拥有完整的3年随访数据。采用负二项回归的广义结构方程模型来估计每个生物标志物每增加1个标准差单位（Δ = +1SD）时，3年随访时探诊深度（PPD）≥4 mm且探诊出血（BOP）的牙齿数量这一结局的回归系数（β）。在调整多个协变量后，基线ICAM-1和VCAM-1对PPD≥4 mm且BOP的牙齿对数转换数量有显著直接影响（β分别为：0.16；95%置信区间：0.02 - 0.30；β为：0.15；95%置信区间：0.02 - 0.30）。基线hs-CRP通过ICAM-1对PPD≥4 mm且BOP的牙齿对数转换数量显示出显著间接影响（β为：4.84；95%置信区间：0.27 - 9.42））。因此，在超重/肥胖的西班牙裔成年人中，血清ICAM-1和VCAM-1升高对3年随访时牙周炎的预测水平有显著直接影响，而hs-CRP升高有显著间接影响。
