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一项前瞻性、随机、开放标签研究，比较氯硝西泮与去甲替林对40岁及以上患有不宁腿综合征女性生活质量的疗效和安全性。

A Prospective, Randomized, Open-Label Study Comparing the Efficacy and Safety of Clonazepam versus Nortriptyline on Quality of Life in 40+ Years old Women Presenting with Restless Leg Syndrome.

作者信息

Tandon Vishal R, Mahajan Annil, Sharma Sudhaa, Khajuria Vijay

机构信息

Department of Pharmacology and Therapeutic, Government Medical College, Jammu, Jammu and Kashmir, India.

Department of General Medicine, Government Medical College, Jammu, Jammu and Kashmir, India.

出版信息

J Midlife Health. 2018 Jul-Sep;9(3):135-139. doi: 10.4103/jmh.JMH_25_18.

DOI:10.4103/jmh.JMH_25_18
PMID:30294185
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6166424/
Abstract

INTRODUCTION

Restless legs syndrome (RLS) is a neurological disorder characterized by an urge to move the legs usually accompanied by unpleasant leg sensations. RLS also impacts health related quality of life (QOL) in patients suffering from it. Further, it affects women more than men. Although a voluminous literature of studies is available evaluating the role of benzodiazepines (clonazepam and antidepressant (nortriptyline) in the treatment of RLS, but to the best of our knowledge, no comparative study is available comparing both of these drugs for efficacy and safety for the treatment of RLS QoL among 40 + years old women.

MATERIALS AND METHODS

A prospective, randomized, open label comparative study was conducted in Postgraduate Department of Pharmacology in collaboration with the Department of General Medicine, Government Medical College, Jammu, a tertiary care teaching hospital for 1 year.

CONCLUSION

Clonazepam proved to be significantly better in improving RLSQoL score. Difference between respective baselines of both groups was statistically insignificant.

摘要

引言

不安腿综合征（RLS）是一种神经系统疾病，其特征是腿部有活动冲动，通常伴有腿部不适感。RLS也会影响患有该疾病患者的健康相关生活质量（QOL）。此外，女性受其影响比男性更严重。尽管有大量研究文献评估苯二氮䓬类药物（氯硝西泮）和抗抑郁药（去甲替林）在RLS治疗中的作用，但据我们所知，尚无比较这两种药物对40岁以上女性RLS QoL治疗疗效和安全性的对照研究。

材料与方法

在查谟政府医学院三级护理教学医院的药理学研究生部与普通医学部合作进行了一项为期1年的前瞻性、随机、开放标签对照研究。

结论

氯硝西泮在改善RLS QoL评分方面被证明明显更好。两组各自基线之间的差异无统计学意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5584/6166424/c18952eab832/JMH-9-135-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5584/6166424/9c3238e150c2/JMH-9-135-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5584/6166424/c18952eab832/JMH-9-135-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5584/6166424/9c3238e150c2/JMH-9-135-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5584/6166424/c18952eab832/JMH-9-135-g004.jpg

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