对膦甲酸和膦乙酸耐药的疱疹病毒突变体的特征
Characteristics of herpesvirus mutants resistant to phosphonoformate and phosphonoacetate.
作者信息
Eriksson B, Oberg B
出版信息
Antimicrob Agents Chemother. 1979 Jun;15(6):758-62. doi: 10.1128/AAC.15.6.758.
Abstract
Mutants of herpes simplex virus type 1, resistant to phosphonoformate (PFA) and phosphonoacetate (PAA), have been selected in cell culture. The PFA-resistant mutant (HSV-PFA(r)) and the PAA-resistant mutant (HSV-PAA(r)) were also resistant to PAA and PFA, respectively. This cross-resistance indicates that PFA and PAA interact at the same site. The HSV-PFA(r) had a decreased susceptibility to vidarabine, but no difference in sensitivity to idoxuridine (5-iodo-2'-deoxyuridine) was observed when compared to the wild type. The induced deoxyribonucleic acid polymerases isolated from cells infected with HSV-PFA(r) and HSV-PAA(r) were both cross-resistant to inhibition by PFA and PAA. No increased resistance to vidarabine triphosphate could be observed, but the susceptibility to inhibition by pyrophosphate was about two times lower. None of the mutants showed any increased temperature sensitivity
摘要
在细胞培养中筛选出了对膦甲酸（PFA）和膦乙酸（PAA）具有抗性的1型单纯疱疹病毒突变体。对PFA具有抗性的突变体（HSV-PFA(r)）和对PAA具有抗性的突变体（HSV-PAA(r)）也分别对PAA和PFA具有抗性。这种交叉抗性表明PFA和PAA在同一部位相互作用。HSV-PFA(r)对阿糖腺苷的敏感性降低，但与野生型相比，对碘苷（5-碘-2'-脱氧尿苷）的敏感性没有差异。从感染HSV-PFA(r)和HSV-PAA(r)的细胞中分离出的诱导脱氧核糖核酸聚合酶对PFA和PAA的抑制均具有交叉抗性。未观察到对三磷酸阿糖腺苷的抗性增加，但对焦磷酸抑制的敏感性约低两倍。没有一个突变体表现出温度敏感性增加。
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