呼吸机相关性肺炎患者中抗抗体的高血清阳性率。
High seroprevalence of anti- antibodies in patients with ventilator-associated pneumonia.
作者信息
Dadashi Alireza, Hosseinzadeh Nima
机构信息
Infectious Diseases Research Center, AJA University of Medical Sciences, Tehran, Iran.
出版信息
J Res Med Sci. 2018 Sep 24;23:79. doi: 10.4103/jrms.JRMS_117_18. eCollection 2018.
BACKGROUND
The pathogenesis of ventilator-associated pneumonia (VAP) is not clearly known. Recently, the role of gastric bacterial colonization has been proposed. The role of gastric colonization with in pathogenesis of VAP was determined by comparing the prevalence of in patients with VAP and control participants.
MATERIALS AND METHODS
One hundred and eighteen mechanically ventilated patients were divided into two groups; 59 participants with VAP and 59 without VAP. Serologic tests for were registered.
RESULTS
Mean age in seropositive patients was significantly higher. About 71.2% in VAP group and 61.01% in controls were IgG seropositive ( = 0.24). IgM seropositivity was 23.73% versus 8.47% in VAPs and controls, respectively ( = 0.024). By increasing the time of intubation, more patients became seropositive for IgM (Pearson's correlation coefficient = 0.4, = 0.002).
CONCLUSION
IgM seropositivity and serum levels were significantly higher in VAP patients. Furthermore, by increasing the duration of intubation, serum levels for IgM increased significantly.
背景
呼吸机相关性肺炎（VAP）的发病机制尚不清楚。最近，有人提出胃细菌定植的作用。通过比较VAP患者和对照参与者中[细菌名称未给出]的流行情况，确定胃定植[细菌名称未给出]在VAP发病机制中的作用。
材料与方法
118例机械通气患者分为两组；59例VAP患者和59例无VAP患者。记录[细菌名称未给出]的血清学检测结果。
结果
血清阳性患者的平均年龄显著更高。VAP组中约71.2%和对照组中61.01%为IgG血清阳性（P = 0.24）。VAP患者和对照组的IgM血清阳性率分别为23.73%和8.47%（P = 0.024）。随着插管时间的延长，更多患者IgM血清呈阳性（Pearson相关系数 = 0.4，P = 0.002）。
结论
VAP患者的IgM血清阳性率和血清水平显著更高。此外，随着插管时间的延长，IgM血清水平显著升高。
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