Hata Koichi, Koyama Teruhide, Ozaki Etsuko, Kuriyama Nagato, Mizuno Shigeto, Matsui Daisuke, Watanabe Isao, Uehara Ritei, Watanabe Yoshiyuki
Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan.
Endoscopy Department, Kindai University Nara Hospital, 1248-1 Otoda-cho, Ikoma, Nara 630-0293, Japan.
Healthcare (Basel). 2021 Feb 3;9(2):162. doi: 10.3390/healthcare9020162.
The relationship between infection and/or gastric disorders and chronic kidney disease (CKD) has not been elucidated. We investigated the relationship between and/or atrophic gastritis (AG) and chronic kidney disease. In total, 3560 participants (1127 men and 2433 women) were eligible for this cross-sectional study. We divided participants into four study groups: with/without infection and with/without AG. The HP (+) AG (-) group demonstrated a significant association with CKD compared with the HP (-) AG (-) group (adjusted odds ratio, 1.443; 95% confidence interval, 1.047-1.989). In contrast, the HP (+) AG (+) group showed significantly lower adjusted odds of CKD than the HP (-) AG (-) group (adjusted odds ratio, 0.608; 95% confidence interval, 0.402-0.920). infection without AG might be associated with CKD in these participants. Conversely, the HP (+) AG (+) group had lower odds of CKD. Uncovering an association between gastric and renal conditions could lead to development of new treatment strategies.
感染和/或胃部疾病与慢性肾脏病（CKD）之间的关系尚未阐明。我们研究了幽门螺杆菌（HP）感染和/或萎缩性胃炎（AG）与慢性肾脏病之间的关系。共有3560名参与者（1127名男性和2433名女性）符合这项横断面研究的条件。我们将参与者分为四个研究组：有/无HP感染和有/无AG。与HP（-）AG（-）组相比，HP（+）AG（-）组与CKD存在显著关联（校正比值比，1.443；95%置信区间，1.047 - 1.989）。相比之下，HP（+）AG（+）组的CKD校正比值显著低于HP（-）AG（-）组（校正比值比，0.608；95%置信区间，0.402 - 0.920）。在这些参与者中，无AG的HP感染可能与CKD有关。相反，HP（+）AG（+）组患CKD的几率较低。揭示胃部和肾脏状况之间的关联可能会带来新治疗策略的发展。
