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Position Paper: The Role of Controlled Drug Delivery for Periodontitis.立场文件:控释给药在牙周炎治疗中的作用
J Periodontol. 2000 Jan;71(1):125-140. doi: 10.1902/jop.2000.71.1.125.
2
Effectiveness of a diode laser in addition to non-surgical periodontal therapy: study of intervention.除非手术牙周治疗外,二极管激光的有效性:干预性研究。
Ann Stomatol (Roma). 2015 May 18;6(1):15-20. eCollection 2015 Jan-Mar.
3
Clinical and biochemical effects of diode laser as an adjunct to nonsurgical treatment of chronic periodontitis: a randomized, controlled clinical trial.二极管激光辅助非手术治疗慢性牙周炎的临床及生化效应:一项随机对照临床试验
Lasers Med Sci. 2014 Jan;29(1):37-46. doi: 10.1007/s10103-012-1230-0. Epub 2012 Nov 16.
4
Clinical effectiveness of diode laser therapy as an adjunct to non-surgical periodontal treatment: a randomized clinical study.二极管激光治疗作为非手术牙周治疗的辅助手段的临床效果:一项随机临床研究。
J Periodontol. 2013 Aug;84(8):1111-7. doi: 10.1902/jop.2012.110708. Epub 2012 Oct 17.
5
To assess the effectiveness of a chlorhexidine chip in the treatment of chronic periodontitis: A clinical and radiographic study.评估洗必泰芯片治疗慢性牙周炎的有效性:一项临床和影像学研究。
J Indian Soc Periodontol. 2011 Apr;15(2):139-46. doi: 10.4103/0972-124X.84383.
6
Biological effects of a semiconductor diode laser on human periodontal ligament fibroblasts.半导体二极管激光对人牙周膜成纤维细胞的生物学效应。
J Periodontal Implant Sci. 2010 Jun;40(3):105-10. doi: 10.5051/jpis.2010.40.3.105. Epub 2010 Jun 25.
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Gingival curettage study comparing a laser treatment to hand instruments.牙龈刮治术研究:比较激光治疗与手动器械
Lasers Med Sci. 2011 Jan;26(1):7-11. doi: 10.1007/s10103-009-0732-x. Epub 2009 Sep 30.
8
Use of diode laser 980 nm as adjunctive therapy in the treatment of chronic periodontitis. A randomized controlled clinical trial.使用980纳米二极管激光作为慢性牙周炎治疗的辅助疗法。一项随机对照临床试验。
New Microbiol. 2008 Oct;31(4):513-8.
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The effect of laser therapy as an adjunct to non-surgical periodontal treatment in subjects with chronic periodontitis: a systematic review.激光治疗作为慢性牙周炎患者非手术牙周治疗辅助手段的效果:一项系统评价。
J Periodontol. 2008 Nov;79(11):2021-8. doi: 10.1902/jop.2008.080197.
10
Effect of a controlled-release chlorhexidine chip on clinical and microbiological parameters and prostaglandin E2 levels in gingival crevicular fluid.缓释洗必泰芯片对临床和微生物学参数以及龈沟液中前列腺素E2水平的影响。
J Periodontol. 2006 Mar;77(3):437-43. doi: 10.1902/jop.2006.050105.

一项比较局部应用洗必泰芯片和二极管激光作为非手术牙周治疗辅助手段疗效的临床微生物学研究。

A clinico-microbiologic study comparing the efficacy of locally delivered chlorhexidine chip and diode LASER as an adjunct to non-surgical periodontal therapy.

作者信息

Bansal Vrishti, Gupta Rajan, Dahiya Parveen, Kumar Mukesh, Samlok Japnit Kaur

机构信息

Department of Periodontics, Himachal Institutes of Dental Sciences, Paonta Sahib, Himachal Pradesh, India.

出版信息

J Oral Biol Craniofac Res. 2019 Jan-Mar;9(1):67-72. doi: 10.1016/j.jobcr.2018.09.001. Epub 2018 Sep 5.

DOI:10.1016/j.jobcr.2018.09.001
PMID:30294538
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6170259/
Abstract

BACKGROUND

Considering the microbial etiology of the periodontal disease, the periodontal therapy aims to control or abolish the pathogenic microbes. The gold standard scaling and root planing procedure has been used since time immemorial but the drawbacks associated with it have led to the development of various adjunctive means. The current study was therefore, performed to comparatively assess the efficacy of local delivery of chlorhexidine and 808-nm diode LASER as an appurtenance to scaling and root planing in patients with chronic periodontitis.

METHODS

In a randomized split mouth evaluation, 30 patients having probing depth of ≥5 mm which bled on probing at least at 3 different sites were included. At baseline, the evaluation of plaque index, bleeding index, probing pocket depth and clinical attachment level was done and the microbial samples were collected for the assessment of spirochetes, motile rods and coccoid cells. The 3 selected sites of each subject were allocated to 3 different groups A, B, C viz; Scaling and root planing (SRP) + chlorhexidine chip, SRP + diode LASER and SRP respectively. The patients were recalled after 4 weeks to re-evaluate the clinical and microbiological parameters.

RESULTS

All the parameters significantly reduced from baseline to 4 weeks in all the 3 groups. Intergroup comparisons revealed remarkable difference between group A and C and group B and C, respectively; no notably significant difference was found between group A and B.

CONCLUSION

The additional use of LASER and chlorhexidine chip assures anti-inflammatory effect and anti-microbial effect that allows reduction in bacterial counts and promotes healing. The use of adjuncts have been found to be efficacious in controlling disease and promoting periodontal health and thereby reducing the need for surgical procedures to be undertaken.

摘要

背景

考虑到牙周病的微生物病因,牙周治疗旨在控制或消除致病微生物。自古以来就一直使用金标准的龈下刮治和根面平整术,但与之相关的缺点促使了各种辅助方法的发展。因此,本研究旨在比较评估氯己定局部给药和808纳米二极管激光作为慢性牙周炎患者龈下刮治和根面平整辅助手段的疗效。

方法

在一项随机分组口内对照评估中,纳入了30名探诊深度≥5毫米且至少在3个不同部位探诊出血的患者。在基线时,对菌斑指数、出血指数、探诊袋深度和临床附着水平进行评估,并收集微生物样本以评估螺旋体、活动杆菌和球菌细胞。将每个受试者的3个选定部位分别分配到3个不同的组A、B、C,即:龈下刮治和根面平整(SRP)+氯己定芯片组、SRP+二极管激光组和SRP组。4周后召回患者重新评估临床和微生物学参数。

结果

所有3组的所有参数从基线到4周均显著降低。组间比较显示,A组和C组、B组和C组之间分别存在显著差异;A组和B组之间未发现显著差异。

结论

额外使用激光和氯己定芯片可确保抗炎和抗菌效果,从而减少细菌数量并促进愈合。已发现使用辅助手段在控制疾病和促进牙周健康方面有效,从而减少了进行外科手术的必要性。