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评估洗必泰芯片治疗慢性牙周炎的有效性:一项临床和影像学研究。

To assess the effectiveness of a chlorhexidine chip in the treatment of chronic periodontitis: A clinical and radiographic study.

作者信息

Grover Vishakha, Kapoor Anoop, Malhotra Ranjan, Battu Virinder Singh, Bhatia Archana, Sachdeva Sonia

机构信息

Department of Periodontology and Oral Implantology, National Dental College and Hospital, Gulabgarh, Mohali, Punjab, India.

出版信息

J Indian Soc Periodontol. 2011 Apr;15(2):139-46. doi: 10.4103/0972-124X.84383.

Abstract

CONTEXT

Controlled local delivery of disinfecting agents has been demonstrated to be efficient in improving the outcome of periodontal therapy.

AIMS

The aim of the present study was to evaluate the efficacy of a controlled-release biodegradable chlorhexidine chip (Periocol CG) when used as an adjunct to scaling and root planing in the treatment of periodontitis.

SETTINGS AND DESIGN

The study was carried out as randomized controlled two-group parallel clinical trial.

MATERIALS AND METHODS

Forty patients in the age group of 30-65 years suffering from mild to moderate chronic periodontitis, having pocket depth ranging between 5 and 8 mm, were selected for the study. At the screening visit, complete history taking, periodontal examination and full-mouth supragingival scaling was carried out for each patient. At the baseline visit (on the 7(th) day), all clinical parameters and radiographic parameters were recorded at selected sites and patients were randomly assigned to either the control group (group A) or the treatment group (group B). All patients in both the groups received complete subgingival scaling and root planing. Then, in group B, chlorhexidine chip (Periocol CG) was inserted at the selected site. Patients were recalled at 1 month, 2 months and 3 months from the baseline for recording clinical observations, and radiographic parameters were recorded at the end of the study.

STATISTICAL ANALYSIS

Mean, standard deviation, Chi-square test, "t" test for equality of means and paired samples correlations were used.

RESULTS

There was a statistically significant clinical attachment gain, reduction in bleeding index scores, probing pocket depth reduction and bone gain in both the groups, but group B showed better results than group A, and these differences were statistically significant.

CONCLUSIONS

The results of this study show that chlorhexidine chip (PerioCol-CG) is an effective adjunctive therapy to scaling and root planing in the treatment of chronic periodontitis.

摘要

背景

已证明消毒剂的可控局部递送在改善牙周治疗效果方面是有效的。

目的

本研究的目的是评估控释可生物降解洗必泰芯片(Periocol CG)作为牙周炎洁治和根面平整治疗辅助手段的疗效。

设置与设计

该研究作为随机对照两组平行临床试验进行。

材料与方法

选择年龄在30 - 65岁、患有轻度至中度慢性牙周炎、牙周袋深度在5至8毫米之间的40例患者进行研究。在筛查访视时,对每位患者进行完整的病史采集、牙周检查和全口龈上洁治。在基线访视(第7天)时,记录选定部位的所有临床参数和影像学参数,并将患者随机分为对照组(A组)或治疗组(B组)。两组所有患者均接受完整的龈下刮治和根面平整。然后,在B组中,将洗必泰芯片(Periocol CG)插入选定部位。从基线开始在1个月、2个月和3个月对患者进行回访以记录临床观察结果,并在研究结束时记录影像学参数。

统计分析

使用均值、标准差、卡方检验、均值相等的“t”检验和配对样本相关性分析。

结果

两组在临床附着获得、出血指数评分降低、探诊牙周袋深度减小和骨增量方面均有统计学显著差异,但B组结果优于A组,且这些差异具有统计学意义。

结论

本研究结果表明,洗必泰芯片(PerioCol - CG)是慢性牙周炎洁治和根面平整治疗的有效辅助治疗方法。

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