Baeten Jeremy T, de Jong Jill L O
Department of Pediatrics, University of Chicago, Chicago, IL, United States.
Front Cell Dev Biol. 2018 Sep 20;6:115. doi: 10.3389/fcell.2018.00115. eCollection 2018.
The zebrafish animal model is gaining increasing popularity as a tool for studying human disease. Over the past 15 years, many models of leukemia and other hematological malignancies have been developed in the zebrafish. These confer some significant advantages over similar models in other animals and systems, representing a powerful resource for investigation of the molecular basis of human leukemia. This review discusses the various zebrafish models of lymphoid and myeloid leukemia available, the major discoveries that have been made possible by them, and opportunities for future exploration.
斑马鱼动物模型作为一种研究人类疾病的工具正越来越受欢迎。在过去15年里，斑马鱼中已开发出许多白血病和其他血液系统恶性肿瘤的模型。这些模型相对于其他动物和系统中的类似模型具有一些显著优势，是研究人类白血病分子基础的强大资源。本综述讨论了现有的各种淋巴样和髓样白血病斑马鱼模型、由它们促成的主要发现以及未来探索的机会。
