NHC Key Laboratory of Human Disease Comparative Medicine Beijing China.
Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases Beijing China.
Animal Model Exp Med. 2021 Feb 3;4(1):71-76. doi: 10.1002/ame2.12144. eCollection 2021 Mar.
Myelodysplastic syndrome (MDS) is a malignant tumor of the hematological system characterized by long-term, progressive refractory hemocytopenia. In addition, the risk of leukemia is high, and once it develops, the course of acute leukemia is short with poor curative effect. Animal models are powerful tools for studying human diseases and are highly effective preclinical platforms. Animal models of MDS can accurately show genetic aberrations and hematopoietic clone phenotypes with similar cellular features (such as impaired differentiation and increased apoptosis), and symptoms can be used to assess existing treatments. Animal models are also helpful for understanding the pathogenesis of MDS and its relationship with acute leukemia, which helps with the identification of candidate genes related to the MDS phenotype. This review summarizes the current status of animal models used to research myelodysplastic syndrome (MDS).
骨髓增生异常综合征（MDS）是一种血液系统的恶性肿瘤，其特征为长期、进行性难治性血细胞减少。此外，白血病的风险较高，一旦发展为白血病，其病程呈急性白血病样，疗效差。动物模型是研究人类疾病的有力工具，也是高效的临床前研究平台。MDS 的动物模型可准确显示具有相似细胞特征（如分化障碍和凋亡增加）的遗传异常和造血克隆表型，可用于评估现有治疗方法的疗效。动物模型也有助于了解 MDS 的发病机制及其与急性白血病的关系，有助于确定与 MDS 表型相关的候选基因。本文综述了用于研究骨髓增生异常综合征（MDS）的动物模型的现状。
