儿茶酚胺能操纵改变跨认知状态的动态网络拓扑结构。
Catecholaminergic manipulation alters dynamic network topology across cognitive states.
作者信息
Shine James M, van den Brink Ruud L, Hernaus Dennis, Nieuwenhuis Sander, Poldrack Russell A
机构信息
Department of Psychology, Stanford University, Stanford, CA, USA.
Institute of Psychology, Leiden University, Leiden, The Netherlands.
出版信息
Netw Neurosci. 2018 Sep 1;2(3):381-396. doi: 10.1162/netn_a_00042. eCollection 2018.
The human brain is able to flexibly adapt its information processing capacity to meet a variety of cognitive challenges. Recent evidence suggests that this flexibility is reflected in the dynamic reorganization of the functional connectome. The ascending catecholaminergic arousal systems of the brain are a plausible candidate mechanism for driving alterations in network architecture, enabling efficient deployment of cognitive resources when the environment demands them. We tested this hypothesis by analyzing both resting-state and task-based fMRI data following the administration of atomoxetine, a noradrenaline reuptake inhibitor, compared with placebo, in two separate human fMRI studies. Our results demonstrate that the manipulation of central catecholamine levels leads to a reorganization of the functional connectome in a manner that is sensitive to ongoing cognitive demands.
人类大脑能够灵活调整其信息处理能力，以应对各种认知挑战。最近的证据表明，这种灵活性体现在功能连接组的动态重组中。大脑中上行的儿茶酚胺能唤醒系统是驱动网络架构改变的一个合理候选机制，当环境需要时，它能使认知资源得到有效调配。在两项独立的人类功能磁共振成像（fMRI）研究中，我们通过分析服用去甲肾上腺素再摄取抑制剂托莫西汀后与服用安慰剂后的静息态和任务态fMRI数据来验证这一假设。我们的结果表明，对中枢儿茶酚胺水平的调控会导致功能连接组的重组，且这种重组方式对当前的认知需求敏感。
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