Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.
Immunol Rev. 2018 Nov;286(1):6-22. doi: 10.1111/imr.12709.
The study of the immune system has shifted from a purely dichotomous separation between the innate and adaptive arms to one that is now highly complex and reshaping our ideas of how steady-state health is assured. It is now clear that immune cells do not neatly fit into these two streams and immune homeostasis depends on continual dialogue between multiple lineages of the innate (including dendritic cells, innate lymphoid cells, and unconventional lymphocytes) and adaptive (T and B lymphocytes) arms together with a finely tuned synergy between the host and microbes which is essential to ensure immune homeostasis. Innate lymphoid cells are critical players in this new landscape. Here, we discuss recent studies that have elucidated in detail the development of ILCs from their earliest progenitors and examine factors that influence their identification and ability to drive immune homeostasis and long-term immune protection.
免疫系统的研究已经从先天免疫和适应性免疫之间纯粹的二分法转变为一个高度复杂的领域，正在重塑我们对稳态健康如何得到保证的认识。现在很清楚的是，免疫细胞并不完全符合这两种类型，免疫稳态依赖于先天（包括树突状细胞、先天淋巴细胞和非常规淋巴细胞）和适应性（T 和 B 淋巴细胞）免疫谱系之间的持续对话，以及宿主和微生物之间的精细协同作用，这对于确保免疫稳态至关重要。先天淋巴细胞是这一新领域的关键参与者。在这里，我们讨论了最近的研究，这些研究详细阐明了 ILC 从其最早的前体发育的过程，并研究了影响其鉴定和驱动免疫稳态和长期免疫保护的因素。
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