小鼠经颅直流电刺激（tDCS）
Transcranial Direct Current Stimulation (tDCS) in Mice.
作者信息
de Souza Nicolau Eduardo, de Alvarenga Kevin Augusto Farias, Tenza-Ferrer Helia, Nogueira Matheus Carvalho Alves, Rezende Fernanda Donizete, Nicolau Nycolle Ferreira, Collodetti Mélcar, de Miranda Débora Marques, Magno Luiz Alexandre Viana, Romano-Silva Marco Aurélio
机构信息
Centro de Tecnologia em Medicina Molecular (CTMM), Faculdade de Medicina, Universidade Federal de Minas Gerais.
Centro de Tecnologia em Medicina Molecular (CTMM), Faculdade de Medicina, Universidade Federal de Minas Gerais;
出版信息
J Vis Exp. 2018 Sep 23(139):58517. doi: 10.3791/58517.
Abstract
Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique proposed as an alternative or complementary treatment for several neuropsychiatric diseases. The biological effects of tDCS are not fully understood, which is in part explained due to the difficulty in obtaining human brain tissue. This protocol describes a tDCS mouse model that uses a chronically implanted electrode allowing the study of the long-lasting biological effects of tDCS. In this experimental model, tDCS changes the cortical gene expression and offers a prominent contribution to the understanding of the rationale for its therapeutic use.
摘要
经颅直流电刺激（tDCS）是一种非侵入性神经调节技术，被提议作为多种神经精神疾病的替代或补充治疗方法。tDCS的生物学效应尚未完全明确，部分原因是获取人类脑组织存在困难。本方案描述了一种tDCS小鼠模型，该模型使用长期植入电极，可用于研究tDCS的长期生物学效应。在这个实验模型中，tDCS改变了皮层基因表达，为理解其治疗用途的原理做出了重要贡献。
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