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Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology.

作者信息

Maack Christoph, Lehrke Michael, Backs Johannes, Heinzel Frank R, Hulot Jean-Sebastien, Marx Nikolaus, Paulus Walter J, Rossignol Patrick, Taegtmeyer Heinrich, Bauersachs Johann, Bayes-Genis Antoni, Brutsaert Dirk, Bugger Heiko, Clarke Kieran, Cosentino Francesco, De Keulenaer Gilles, Dei Cas Alessandra, González Arantxa, Huelsmann Martin, Iaccarino Guido, Lunde Ida Gjervold, Lyon Alexander R, Pollesello Piero, Rena Graham, Riksen Niels P, Rosano Giuseppe, Staels Bart, van Laake Linda W, Wanner Christoph, Farmakis Dimitrios, Filippatos Gerasimos, Ruschitzka Frank, Seferovic Petar, de Boer Rudolf A, Heymans Stephane

机构信息

Comprehensive Heart Failure Center, University Clinic Würzburg, Würzburg, Germany.

Department of Internal Medicine I, University Hospital Aachen, Aachen, Germany.

出版信息

Eur Heart J. 2018 Dec 21;39(48):4243-4254. doi: 10.1093/eurheartj/ehy596.

DOI:10.1093/eurheartj/ehy596
PMID:30295797
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6302261/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a9f/6302261/ddcfa07c8abd/ehy596f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a9f/6302261/82d3a4a5aee7/ehy596f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a9f/6302261/78c785aac3e6/ehy596f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a9f/6302261/a17d43f1354e/ehy596f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a9f/6302261/9fbeb40c8225/ehy596f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a9f/6302261/ddcfa07c8abd/ehy596f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a9f/6302261/82d3a4a5aee7/ehy596f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a9f/6302261/78c785aac3e6/ehy596f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a9f/6302261/a17d43f1354e/ehy596f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a9f/6302261/9fbeb40c8225/ehy596f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a9f/6302261/ddcfa07c8abd/ehy596f5.jpg

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Metabolic remodelling in heart failure.心力衰竭中的代谢重编程。
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Mitochondrial uncoupling, ROS generation and cardioprotection.线粒体解偶联、ROS 生成与心脏保护。
Biochim Biophys Acta Bioenerg. 2018 Sep;1859(9):940-950. doi: 10.1016/j.bbabio.2018.05.019. Epub 2018 May 31.
3
Calcium Signaling and Reactive Oxygen Species in Mitochondria.钙信号与线粒体中的活性氧物种。
一种反映临床疾病进展的改良糖尿病性心肌病小鼠模型的深度表型分析。
Diabetol Metab Syndr. 2025 Aug 14;17(1):334. doi: 10.1186/s13098-025-01913-3.
4
The mitochondrial hub gene UCHL1 May serve as a potential biomarker for diagnosing diabetic cardiomyopathy: a comprehensive integration of biological pathways.线粒体枢纽基因UCHL1可能作为诊断糖尿病性心肌病的潜在生物标志物:生物途径的综合整合
BMC Med Genomics. 2025 Aug 11;18(1):129. doi: 10.1186/s12920-025-02199-0.
5
Mechano-energetic uncoupling in heart failure.心力衰竭中的机械-能量解偶联
Nat Rev Cardiol. 2025 Jun 22. doi: 10.1038/s41569-025-01167-6.
6
The impact of diabetes duration and glycemic control on ejection fraction in heart failure patients.糖尿病病程和血糖控制对心力衰竭患者射血分数的影响。
Acta Diabetol. 2025 May 7. doi: 10.1007/s00592-025-02519-x.
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