Monaghan D T, Geddes J W, Yao D, Chung C, Cotman C W
Neurosci Lett. 1987 Jan 14;73(2):197-200. doi: 10.1016/0304-3940(87)90017-6.
Quantitative autoradiography was used to determine the density and distribution of [3H]1-[1-(2-thienyl)-cyclohexyl]piperidine ([3H]TCP) binding sites in human hippocampal tissue sections from control and Alzheimer's disease patients. Some Alzheimer's cases showed no changes in binding site density while other cases showed substantial declines in the CA1 region. [3H]TCP binding in the CA1 region from Alzheimer's patients was reduced an average of 40% while the other hippocampal regions were unaffected. It is proposed that the loss of [3H]TCP sites in the hippocampal CA1 region of certain Alzheimer's cases is associated with the greater cell loss observed in cases of severe Alzheimer's disease.
采用定量放射自显影法测定了来自对照患者和阿尔茨海默病患者的人脑海马组织切片中[3H]1-[1-(2-噻吩基)-环己基]哌啶([3H]TCP)结合位点的密度和分布。一些阿尔茨海默病病例的结合位点密度没有变化，而其他病例在CA1区域则出现了显著下降。阿尔茨海默病患者CA1区域的[3H]TCP结合平均减少了40%，而其他海马区域未受影响。有人提出，某些阿尔茨海默病病例海马CA1区域[3H]TCP位点的丧失与严重阿尔茨海默病病例中观察到的更多细胞丢失有关。
