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[使用γ磷保护大脑免受迟发性辐射损伤]

[Use of gammaphos for protecting the brain from delayed radiation damage].

作者信息

Shaposhnikova V V, Levitman M Kh, Plotnikova E D, Eĭdus L Kh

出版信息

Radiobiologiia. 1987 Jan-Feb;27(1):37-40.

PMID:3029800
Abstract

The influence of a radioprotector, gammaphos, on the development of delayed vascular changes and necrosis in rat brain following local brain irradiation with 25 Gy was investigated. The radioprotective effect was manifested by both the morphometric parameters of vessels and the survival rate and relative number of animals with gross vascular abnormalities and brain necrosis. There was a causative relationship between the development of gross vascular abnormalities and the occurrence of brain necrosis after exposure to moderate radiation doses.

摘要

研究了辐射防护剂γ-磷(gammaphos)对大鼠脑部局部照射25 Gy后迟发性血管变化和坏死发展的影响。辐射防护作用通过血管的形态学参数、生存率以及出现明显血管异常和脑坏死的动物的相对数量得以体现。在中等辐射剂量照射后,明显血管异常的发展与脑坏死的发生之间存在因果关系。

相似文献

3
Protection of microvasculature in rat brain against late radiation injury by gammaphos.
Int J Radiat Oncol Biol Phys. 1988 Nov;15(5):1197-201. doi: 10.1016/0360-3016(88)90204-0.

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