肥胖是非洲男性（无论是否患有2型糖尿病）循环成纤维细胞生长因子-21水平的关键相关因素。
Adiposity Is a Key Correlate of Circulating Fibroblast Growth Factor-21 Levels in African Males with or without Type 2 Diabetes Mellitus.
作者信息
Mashili Fredirick L, Ramaiya Kaushik, Lutale Janet, Njelekela Marina, Francis Filbert, Zierath Juleen, Krook Anna
机构信息
Department of Physiology, Muhimbili University of Health and Allied Sciences, Box 65001, Dar es Salaam, Tanzania.
Tanzania Diabetes Association, Box 65201, Dar Es Salaam, Tanzania.
出版信息
J Obes. 2018 Sep 12;2018:7461903. doi: 10.1155/2018/7461903. eCollection 2018.
BACKGROUND
Fibroblast growth factor-21 is an endocrine regulator with therapeutic and diagnostic potential. The levels and pattern of circulating FGF-21 have been described mainly in European and Asian populations. Given its strong association with adiposity, and the reported ethnic variabilities in body composition, examining FGF-21 in an African population is crucial.
METHODS
We measured levels of circulating FGF-21 in 207 overweight and obese Tanzanian males with or without type 2 diabetes mellitus (T2DM), and using statistical approaches, we explored their relationship with anthropometric and biochemical parameters.
RESULTS
Consistent with previous reports from European and Asian populations, we found higher levels of FGF-21 in people with T2DM compared to those without the disease. Based on statistical models, measures of adiposity explained up to 59% of the variability in FGF-21 levels in the circulation.
CONCLUSION
Levels of circulating FGF-21 in overweight and obese African males are higher in T2DM and strongly correlate with measures of adiposity.
背景
成纤维细胞生长因子-21是一种具有治疗和诊断潜力的内分泌调节因子。循环中FGF-21的水平和模式主要在欧洲和亚洲人群中进行了描述。鉴于其与肥胖的密切关联，以及报道的不同种族在身体组成方面的差异，在非洲人群中检测FGF-21至关重要。
方法
我们测量了207名患有或未患有2型糖尿病（T2DM）的超重和肥胖坦桑尼亚男性的循环FGF-21水平，并使用统计方法探讨了其与人体测量学和生化参数的关系。
结果
与欧洲和亚洲人群先前的报道一致，我们发现患有T2DM的人循环中FGF-21水平高于未患该疾病的人。基于统计模型，肥胖指标解释了循环中FGF-21水平高达59%的变异性。
结论
超重和肥胖非洲男性循环中FGF-21的水平在T2DM患者中较高，且与肥胖指标密切相关。
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