正常受试者及新诊断的2型糖尿病患者的循环成纤维细胞生长因子21水平。
Circulating FGF-21 levels in normal subjects and in newly diagnose patients with Type 2 diabetes mellitus.
作者信息
Chen W-W, Li L, Yang G-Y, Li K, Qi X-Y, Zhu W, Tang Y, Liu H, Boden G
机构信息
Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
出版信息
Exp Clin Endocrinol Diabetes. 2008 Jan;116(1):65-8. doi: 10.1055/s-2007-985148. Epub 2007 Oct 9.
Fibroplast growth factor (FGF-21) is a recently discovered metabolic regulator. Its pathophysiologic role in humans remains unknown. In this study, we have investigated whether or not plasma FGF-21 level was different in patients with type 2 diabetes mellitus (T2DM) and non-diabetic controls. We also assessed associations between plasma FGF-21 body composition and several metabolic parameters. Fasting FGF-21 levels were significantly increased in patients with T2DM compared with controls (1.82+/-0.65 VS. 1.53+/-0.60 microg/L, P<0.05). In T2DM patients, fasting plasma FGF-21 correlate negatively with fasting blood glucose ( R= -0.31, P<0.05). Multiple regression analysis showed that FBG, plasma insulin and HOMA (IS) were independent influencing plasma FGF-21 levels. The present work suggests a potential role for FGF-21 in the pathogenesis of insulin resistance and T2DM.
成纤维细胞生长因子（FGF - 21）是最近发现的一种代谢调节因子。其在人类中的病理生理作用尚不清楚。在本研究中，我们调查了2型糖尿病（T2DM）患者与非糖尿病对照者的血浆FGF - 21水平是否存在差异。我们还评估了血浆FGF - 21、身体组成与几个代谢参数之间的关联。与对照组相比，T2DM患者的空腹FGF - 21水平显著升高（1.82±0.65对1.53±0.60微克/升，P<0.05）。在T2DM患者中，空腹血浆FGF - 21与空腹血糖呈负相关（R = -0.31，P<0.05）。多元回归分析表明，空腹血糖、血浆胰岛素和HOMA（胰岛素敏感性指数）是影响血浆FGF - 21水平的独立因素。目前的研究表明FGF - 21在胰岛素抵抗和T2DM的发病机制中具有潜在作用。
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