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ω-3 脂肪酸对大鼠脑内皮细胞阿尔茨海默病的保护作用。

Protective effects of omega-3 fatty acids against Alzheimer's disease in rat brain endothelial cells.

机构信息

Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China.

Department of Neurology, Nankai University Fourth Center Hospital Neurology Center, Tianjin, China.

出版信息

Brain Behav. 2018 Nov;8(11):e01037. doi: 10.1002/brb3.1037. Epub 2018 Oct 8.

DOI:10.1002/brb3.1037
PMID:30298620
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6236236/
Abstract

OBJECTIVES

Omega-3 fatty acids are well-known unsaturated fatty acids that are essential for growth and development in animals. They primarily participate in the development of intelligence, the nervous system, and vision, and the metabolism of neurotransmitters. Omega-3 fatty acids have been widely studied in the treatment of Alzheimer's disease (AD). Omega-3 fatty acids are known to have neuroprotective effects due to their antioxidant capacity. Rotenone has been shown to induce neurotoxicity in vitro.

METHODS

We investigated the protective effects of omega-3 fatty acids against AD in rat brain microvascular endothelial cells (RBMVECs) in vitro. Lipid peroxidation, reactive oxygen species (ROS), glutathione peroxidase (Gpx), reduced glutathione (GSH), superoxide dismutase (SOD), and catalase levels were evaluated in RBMVECs. Flow cytometry was performed to assess apoptosis.

RESULTS

Lipid peroxidation and ROS were reduced in RBMVECs following incubation with omega-3 fatty acids. Catalase, Gpx, and SOD were increased in RBMVECs following incubation with omega-3 fatty acids. Flow cytometry showed that incubation with omega-3 fatty acids reduced the amount of apoptotic RBMVECs.

CONCLUSION

Our results suggest that omega-3 fatty acids show potential as a therapeutic agent against AD.

摘要

目的

ω-3 脂肪酸是众所周知的不饱和脂肪酸，对动物的生长发育至关重要。它们主要参与智力、神经系统和视力的发育，以及神经递质的代谢。ω-3 脂肪酸在治疗阿尔茨海默病（AD）方面已经得到了广泛的研究。由于其抗氧化能力，ω-3 脂肪酸具有神经保护作用。鱼藤酮已被证明在体外具有神经毒性。

方法

我们研究了 ω-3 脂肪酸对体外大鼠脑微血管内皮细胞（RBMVEC）中 AD 的保护作用。评估了 RBMVEC 中的脂质过氧化、活性氧（ROS）、谷胱甘肽过氧化物酶（Gpx）、还原型谷胱甘肽（GSH）、超氧化物歧化酶（SOD）和过氧化氢酶水平。通过流式细胞术评估细胞凋亡。

结果

ω-3 脂肪酸孵育可降低 RBMVEC 中的脂质过氧化和 ROS。ω-3 脂肪酸孵育可增加 RBMVEC 中的过氧化氢酶、Gpx 和 SOD。流式细胞术显示，ω-3 脂肪酸孵育可减少凋亡的 RBMVEC 数量。

结论

我们的结果表明，ω-3 脂肪酸可能成为治疗 AD 的一种有潜力的治疗药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48fc/6236236/a7112cb590bd/BRB3-8-e01037-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48fc/6236236/3442df9a2a37/BRB3-8-e01037-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48fc/6236236/a9d3b1f89f98/BRB3-8-e01037-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48fc/6236236/3bfd70bd52d7/BRB3-8-e01037-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48fc/6236236/8c88d4953191/BRB3-8-e01037-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48fc/6236236/700c69212528/BRB3-8-e01037-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48fc/6236236/b0971884b2a1/BRB3-8-e01037-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48fc/6236236/0876f1c42bc7/BRB3-8-e01037-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48fc/6236236/21499740a3f2/BRB3-8-e01037-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48fc/6236236/a7112cb590bd/BRB3-8-e01037-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48fc/6236236/3442df9a2a37/BRB3-8-e01037-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48fc/6236236/a9d3b1f89f98/BRB3-8-e01037-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48fc/6236236/3bfd70bd52d7/BRB3-8-e01037-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48fc/6236236/8c88d4953191/BRB3-8-e01037-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48fc/6236236/700c69212528/BRB3-8-e01037-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48fc/6236236/b0971884b2a1/BRB3-8-e01037-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48fc/6236236/0876f1c42bc7/BRB3-8-e01037-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48fc/6236236/21499740a3f2/BRB3-8-e01037-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48fc/6236236/a7112cb590bd/BRB3-8-e01037-g009.jpg

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