School of Basic and Applied Sciences, Dayananda Sagar University, Bangalore, India.
Department of Biotechnology, Sapthagiri College of Engineering, Bangalore, India.
Methods Mol Biol. 2024;2761:209-229. doi: 10.1007/978-1-0716-3662-6_15.
Omega-3 fatty acids play a seminal role in maintaining the structural and functional integrity of the nervous system. These specialized molecules function as precursors for many lipid-based biological messengers. Also, studies suggest the role of these fatty acids in regulating healthy sleep cycles, cognitive ability, brain development, etc. Dietary intake of essential poly unsaturated fatty acids (PUFA) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are foundational to the optimal working of the nervous system. Besides regulating health, these biomolecules have great therapeutic value in treating several diseases, particularly nervous system diseases and disorders. Many recent studies conclusively demonstrated the beneficial effects of Omega-3 fatty acids in treating depression, neuropsychiatric disorders, neurodegenerative disorders, neurochemical disorders, and many other illnesses associated with the nervous system. This chapter summates the multifaceted role of poly unsaturated fatty acids, especially Omega-3 fatty acids (EPA and DHA), in the neuronal health and functioning. The importance of dietary intake of these essential fatty acids, their recommended dosages, bioavailability, the mechanism of their action, and therapeutic values are extensively discussed.
ω-3 脂肪酸在维持神经系统的结构和功能完整性方面起着重要作用。这些特殊的分子是许多基于脂质的生物信使的前体。此外,研究表明这些脂肪酸在调节健康的睡眠周期、认知能力、大脑发育等方面发挥作用。饮食中摄入必需的多不饱和脂肪酸(PUFA),如二十碳五烯酸(EPA)和二十二碳六烯酸(DHA),是神经系统最佳运作的基础。这些生物分子除了调节健康外,在治疗多种疾病方面具有重要的治疗价值,特别是神经系统疾病和紊乱。许多最近的研究都明确证明了 ω-3 脂肪酸在治疗抑郁症、神经精神疾病、神经退行性疾病、神经化学疾病以及许多与神经系统相关的其他疾病方面的有益作用。本章总结了多不饱和脂肪酸,特别是 ω-3 脂肪酸(EPA 和 DHA)在神经元健康和功能方面的多方面作用。广泛讨论了这些必需脂肪酸的饮食摄入、推荐剂量、生物利用度、作用机制和治疗价值。