Gharibi Hamed, Entwistle Marcela R, Ha Sandie, Gonzalez Mariaelena, Brown Paul, Schweizer Donald, Cisneros Ricardo
Department of Public Health, College of Social Sciences, Humanities and Arts, University of California, Merced, CA, USA.
Health Sciences Research Institute, University of California, Merced, CA, USA.
J Asthma. 2019 Oct;56(10):1037-1048. doi: 10.1080/02770903.2018.1523930. Epub 2018 Oct 9.
: The San Joaquin Valley (SJV) exceeds the state and national standards for ozone (O). This study investigates whether short-term exposure to O is associated with asthma emergency department (ED) visits. : We identified 1,101 ED visits in June-September of 2015 in SJV, California, who lived within 15 km of active air monitors. Conditional logistic regression models were used to obtain the odds ratio (OR) and 95% confidence interval (CI) associated with an interquartile (IQR) increase in ozone. We explored the potential effect modification by sex (female and male), race (White, Black and Hispanic), age (2-5, 6-18, 19-40, 41-64 and > = 65) and county (Merced, Madera, Kings, Fresno and Kern). : An IQR range (18.1 ppb) increase in O exposure three days before an asthma attack (lag 3) was associated with a 6.6% [OR: 1.066 (95% CI: 1.032, 1.082)] increase in the odds of having an asthma ED visit. The overall ORs differed across age groups and races/ethnicities, with strongest for children aged 6-18 years [OR: 1.219 (95% CI: 1.159, 1.280)], adults 19-40 years [OR: 1.102 (95% CI: 1.053, 1.154)] and Blacks [OR: 1.159 (95% CI: 1.088, 1.236)], respectively. O exposure was not positively associated with asthma ED visits for Whites, while it was for other underrepresented groups. Fresno had the highest number of asthma ED visits and positive association among all five counties. : We found that O exposure is associated with asthma ED visits in the SJV.
圣华金河谷（SJV）的臭氧（O₃）含量超过了该州和国家标准。本研究调查短期暴露于O₃是否与哮喘急诊就诊相关。我们确定了2015年6月至9月在加利福尼亚州圣华金河谷居住在活跃空气监测仪15公里范围内的1101例急诊就诊病例。使用条件逻辑回归模型来获得与臭氧四分位数间距（IQR）增加相关的比值比（OR）和95%置信区间（CI）。我们探讨了性别（女性和男性）、种族（白人、黑人和西班牙裔）、年龄（2 - 5岁、6 - 18岁、19 - 40岁、41 - 64岁和≥65岁）以及县（默塞德、马德拉、金斯、弗雷斯诺和克恩）的潜在效应修正。哮喘发作前三天（滞后3天）O₃暴露的IQR范围增加（18.1 ppb）与哮喘急诊就诊几率增加6.6% [OR：1.066（95% CI：1.032，1.082）]相关。总体OR在不同年龄组和种族/族裔中有所不同，6 - 18岁儿童最强 [OR：1.219（95% CI：1.159，1.280）]，19 - 40岁成年人 [OR：1.102（95% CI：1.053，1.154）]，黑人 [OR：1.159（95% CI：1.088，1.236）] 分别如此。O₃暴露与白人哮喘急诊就诊无正相关，而与其他代表性不足的群体相关。在所有五个县中，弗雷斯诺的哮喘急诊就诊人数最多且呈正相关。我们发现，在圣华金河谷，O₃暴露与哮喘急诊就诊相关。
