酯酶敏感型谷胱甘肽过硫酸盐供体。
Esterase-Sensitive Glutathione Persulfide Donor.
机构信息
Department of Chemistry and Center for Diagnostics and Therapeutics , Georgia State University , Atlanta , Georgia 30303 , United States.
出版信息
Org Lett. 2018 Oct 19;20(20):6364-6367. doi: 10.1021/acs.orglett.8b02611. Epub 2018 Oct 9.
An esterase-sensitive glutathione persulfide (GSSH) donor (BW-GP-401) is described. The release profile was studied by monitoring the formation of lactone and direct trapping of GSSH with 1-fluoro-2,4-dinitrobenzene (DNFB). The donor was examined for its inhibitory effect toward glyceraldehyde 3-phosphate dehydrogenase (GAPDH). Under highly oxidative conditions, the donor also shows cytoprotective effects in H9c2 cardiomyocytes.
一种酯酶敏感的谷胱甘肽过硫酸盐（GSSH）供体（BW-GP-401）被描述。通过监测内酯的形成和用 1-氟-2,4-二硝基苯（DNFB）直接捕获 GSSH 来研究释放曲线。该供体被检查对甘油醛 3-磷酸脱氢酶（GAPDH）的抑制作用。在高度氧化条件下，供体在 H9c2 心肌细胞中也显示出细胞保护作用。
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