3T 下小儿膝关节软骨和半月板 T2 弛豫时间的发育相关变化。
Maturation-Related Changes in T2 Relaxation Times of Cartilage and Meniscus of the Pediatric Knee Joint at 3 T.
机构信息
1 Department of Radiology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA 19104.
2 Department of Radiology, University of Utah, Salt Lake City, UT.
出版信息
AJR Am J Roentgenol. 2018 Dec;211(6):1369-1375. doi: 10.2214/AJR.18.20026. Epub 2018 Oct 9.
OBJECTIVE
The objective of our study was to use a T2 mapping sequence performed at 3 T to investigate changes in the composition and microstructure of the cartilage and menisci of the pediatric knee joint during maturation.
MATERIALS AND METHODS
This retrospective study was performed of MRI examinations of 76 pediatric knees without internal derangement in 72 subjects (29 boys [mean age, 12.5 years] and 43 girls [mean age, 13.0 years]) who were evaluated with a sagittal T2 mapping sequence. T2 relaxation time values were quantitatively measured in eight cartilage subregions and in the medial and lateral menisci. Wilcoxon rank sum and Kruskal-Wallis tests were used to analyze the relationship between cartilage and meniscus T2 relaxation time values and sex and skeletal maturation, respectively. A multivariate linear regression model was used to investigate the independent association between cartilage T2 relaxation time values and age, weight, and body mass index (BMI [weight in kilograms divided by the square of height in meters]).
RESULTS
There were no significant sex differences (p = 0.26-0.91) in T2 relaxation time values for cartilage or meniscus. T2 relaxation time values in each individual cartilage subregion significantly decreased (p < 0.001) with progressive maturation. T2 relaxation time values in the lateral meniscus significantly increased (p = 0.001) with maturation, whereas T2 relaxation time values in the medial meniscus did not significantly change (p = 0.82). There was a significant association (p < 0.001) between cartilage T2 relaxation time values and age independent of weight and BMI, but no significant association between cartilage T2 relaxation time values and weight (p = 0.06) and BMI (p = 0.20) independent of age.
CONCLUSION
Cartilage T2 relaxation time values significantly decreased in all cartilage subregions and meniscus T2 relaxation time values significantly increased in the lateral meniscus during maturation. These changes in T2 relaxation time values reflect age-related changes in tissue composition and microstructure.
目的
本研究旨在使用 3T 下的 T2 映射序列，研究小儿膝关节软骨和半月板在成熟过程中的成分和微观结构变化。
材料和方法
本回顾性研究纳入了 72 名受试者（29 名男孩，平均年龄 12.5 岁；43 名女孩，平均年龄 13.0 岁）的 76 个无内部紊乱的小儿膝关节 MRI 检查，这些受试者均行矢状 T2 映射序列检查。定量测量了 8 个软骨分区以及内侧和外侧半月板的 T2 弛豫时间值。采用 Wilcoxon 秩和检验和 Kruskal-Wallis 检验分别分析软骨和半月板 T2 弛豫时间值与性别和骨骼成熟度之间的关系。采用多元线性回归模型分析软骨 T2 弛豫时间值与年龄、体重和体重指数（BMI，体重以千克为单位除以身高以米为单位的平方）之间的独立相关性。
结果
软骨或半月板的 T2 弛豫时间值在性别之间无显著差异（p = 0.26-0.91）。随着成熟度的增加，每个单独的软骨分区的 T2 弛豫时间值均显著降低（p < 0.001）。外侧半月板的 T2 弛豫时间值随成熟度显著增加（p = 0.001），而内侧半月板的 T2 弛豫时间值无显著变化（p = 0.82）。软骨 T2 弛豫时间值与年龄呈显著相关（p < 0.001），与体重和 BMI 无关，但与年龄无关，与体重（p = 0.06）和 BMI（p = 0.20）无关。
结论
在成熟过程中，所有软骨分区的软骨 T2 弛豫时间值均显著降低，外侧半月板的 T2 弛豫时间值显著增加。这些 T2 弛豫时间值的变化反映了组织成分和微观结构的年龄相关性变化。
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