3T 下 T2∗ 映射在青少年剥脱性骨软骨炎（JOCD）患者关节软骨评估中的应用。
MRI evaluation of articular cartilage in patients with juvenile osteochondritis dissecans (JOCD) using T2∗ mapping at 3T.
机构信息
Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA; Department of Radiology, University of Minnesota, Minneapolis, MN, USA.
Department of Radiology, University of Minnesota, Minneapolis, MN, USA.
出版信息
Osteoarthritis Cartilage. 2020 Sep;28(9):1235-1244. doi: 10.1016/j.joca.2020.04.001. Epub 2020 Apr 8.
OBJECTIVE
Evaluate articular cartilage by magnetic resonance imaging (MRI) T2∗ mapping within the distal femur and proximal tibia in adolescents with juvenile osteochondritis dissecans (JOCD).
DESIGN
JOCD imaging studies acquired between August 2011 and February 2019 with clinical and T2∗ mapping MRI knee images were retrospectively collected and analyzed for 31 participants (9F/22M, 15.0 ± 3.8 years old) with JOCD lesions in the medial femoral condyle (MFC). In total, N = 32 knees with JOCD lesions and N = 14 control knees were assessed. Mean T2∗ values in four articular cartilage regions-of-interest (MFC, lateral femoral condyle (LFC), medial tibia (MT), and lateral tibia (LT)) and lesion volume were measured and analyzed using Wilcoxon-rank-sum tests and Spearman correlation coefficients (R).
RESULTS
Mean ± standard error T2∗ differences observed between the lesion-sided MFC and the LFC in JOCD-affected knees (28.5 ± 0.9 95% confidence interval [26.8, 30.3] vs 26.3 ± 0.7 [24.8, 27.7] ms, P = 0.088) and between the affected- and control-knee MFC (28.5 ± 0.9 [26.8, 30.3] vs 28.5 ± 0.6 [27.1, 29.9] ms, P = 0.719) were nonsignificant. T2∗ was significantly increased in the lesion-sided MT vs the LT for the JOCD-affected knees (21.5 ± 0.7 [20.1, 22.9] vs 18.0 ± 0.7 [16.5, 19.5] ms, P = 0.002), but this same difference was also observed between the MT and LT in control knees (21.0 ± 0.6 [19.7, 22.3] vs 18.1 ± 1.1 [15.8, 20.4] ms, P = 0.037). There was no significant T2∗ difference between the affected- and control-knee MT (21.5 ± 0.7 [20.1, 22.9] vs 21.0 ± 0.6 [19.7, 22.3] ms, P = 0.905). T2∗ within the lesion-sided MFC was not correlated with patient age (R = 0.20, P = 0.28) or lesion volume (R = 0.06, P = 0.75). T2∗ values were slightly increased near lesions in later-stage JOCD subjects but without statistical significance.
CONCLUSIONS
T2∗ relaxations times were not significantly different from control sites in the articular cartilage overlying JOCD lesions in the MFC or adjacent MT cartilage in early-stage JOCD.
目的
通过 MRI T2* 映射评估青少年骺软骨骨软骨病（JOCD）患者股骨远端和胫骨近端的关节软骨。
设计
回顾性收集 2011 年 8 月至 2019 年 2 月期间获得的 JOCD 影像学研究和临床膝关节 T2* 映射 MRI 图像，对 31 名内侧股骨髁（MFC）有 JOCD 病变的参与者（9 名女性/22 名男性，15.0±3.8 岁）进行评估。共评估了 32 个有 JOCD 病变的膝关节和 14 个对照膝关节。使用 Wilcoxon 秩和检验和 Spearman 相关系数（R）测量和分析四个关节软骨感兴趣区（MFC、外侧股骨髁（LFC）、内侧胫骨（MT）和外侧胫骨（LT））和病变体积的平均 T2* 值。
结果
JOCD 受累膝关节病变侧 MFC 与 LFC 之间（28.5±0.9 95%置信区间 [26.8, 30.3] 与 26.3±0.7 [24.8, 27.7] ms，P=0.088）和受累膝关节与对照膝关节 MFC 之间（28.5±0.9 [26.8, 30.3] 与 28.5±0.6 [27.1, 29.9] ms，P=0.719）的平均 T2* 差异无统计学意义。JOCD 受累膝关节病变侧 MT 与 LT 之间的 T2* 值显著增加（21.5±0.7 [20.1, 22.9] 与 18.0±0.7 [16.5, 19.5] ms，P=0.002），但在对照膝关节中也观察到 MT 和 LT 之间的相同差异（21.0±0.6 [19.7, 22.3] 与 18.1±1.1 [15.8, 20.4] ms，P=0.037）。受累膝关节和对照膝关节 MT 之间的 T2* 值差异无统计学意义（21.5±0.7 [20.1, 22.9] 与 21.0±0.6 [19.7, 22.3] ms，P=0.905）。病变侧 MFC 内的 T2* 值与患者年龄（R=0.20，P=0.28）或病变体积（R=0.06，P=0.75）均无相关性。在 JOCD 晚期患者中，病变附近的 T2* 值略有增加，但无统计学意义。
结论
在 JOCD 早期，MFC 或相邻 MT 软骨的 JOCD 病变上的关节软骨的 T2* 弛豫时间与对照部位无显著差异。
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