National University of Singapore, Department of Surgery, 1E Kent Ridge Road, NUHS Tower Block, Level 8, Singapore 119228, Singapore.
National University of Singapore, Department of Civil and Environmental Engineering, 1 Engineering Drive 2, E1A 08-03, Singapore 117576, Singapore.
Mar Pollut Bull. 2018 Oct;135:475-480. doi: 10.1016/j.marpolbul.2018.07.055. Epub 2018 Jul 24.
Poor microbial water quality jeopardizes the health and safety of food produced by aquaculture farms. Three fish farms and transect sites in Singapore were assessed for microbial water quality and antimicrobial resistance determinants. Of the 33 multidrug resistant E. coli isolated from surface waters of the Johor Straits, 81.8% were ESBL producers. The relative abundance of sul1, qnrA and intI1 genes were higher in sediments than surface waters. Among the surface water samples, higher concentrations (10-10) of beta-lactamases (bla, bla, bla) were detected in the transect sites. This study highlights a potential antimicrobial resistance transmission chain from environmental waters, to animal carriers and humans.
养殖农场生产的水产品的微生物水质不佳会危及人类健康和安全。本研究对新加坡的三个养殖场和三个河道采样点的水质和抗菌药物抗性决定因素进行了评估。在柔佛海峡的地表水中共分离出 33 株多药耐药性大肠杆菌，其中 81.8%为 ESBL 产生菌。在沉积物中的 sul1、qnrA 和 intI1 基因丰度高于地表水。在表层水样中，在河道采样点检测到更高浓度的β-内酰胺酶（blaCTX-M、blaTEM 和 blaOXA）。本研究强调了从环境水体到动物载体和人类的潜在抗菌药物抗性传播链。
