Jang Jun-Pil, Han Jang Mi, Jung Hye Jin, Osada Hiroyuki, Jang Jae-Hyuk, Ahn Jong Seog
Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Republic of Korea.
Department of Pharmaceutical Engineering and Biotechnology, Sun Moon University, Asan 61460, Republic of Korea.
J Microbiol Biotechnol. 2018 Aug 28;28(8):1332-1338. doi: 10.4014/jmb.1806.06046.
In the course of studies to discover natural products with anti-angiogenic properties, two cyclic octapeptides, octaminomycins A () and B (), were isolated from the cultures of sp. RK85-270. Octaminomycins suppressed the vascular endothelial growth factor (VEGF)-induced proliferation, adhesion, tube formation, migration, and invasion of HUVECs. Anti-angiogenic activity was futher confirmed in vivo by the chicken chorioallantoic membrane assay. We also identified that and inhibited the phosphorylation of VEGF receptor 2, AKT, and ERK1/2 and the expression and activities of MMP-2 and MMP-9. These results suggest that and may serve as potential scaffolds for the development of therapeutic agents to angiogenesis-dependent diseases.
