Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Chem Commun (Camb). 2018 Oct 25;54(86):12182-12185. doi: 10.1039/c8cc06945j.
Here, we report a palladium-catalyzed controllable cyclization of vinyl ethylene carbonates that proceeds through formal migration [2+3] and [5+2] cycloadditions, respectively, under mild conditions. The transformation described here affords a series of synthetically versatile 5,7-membered N-heterocycles which are found in natural products and pharmaceuticals with biological and medicinal properties.
在这里，我们报道了一种钯催化的乙烯基碳酸乙烯酯的可控环化反应，该反应分别通过形式迁移[2+3]和[5+2]环加成进行，在温和条件下进行。这里描述的转化提供了一系列具有合成多功能性的 5,7 元 N-杂环化合物，这些化合物存在于具有生物和药用性质的天然产物和药物中。
