亚甲基四氢叶酸还原酶C677T基因多态性与下肢深静脉血栓形成的关系
Relationship between genetic polymorphism of MTHFR C677T and lower extremities deep venous thrombosis.
作者信息
Xu Jiasheng, Li Kexin, Zhou Weimin
机构信息
a Department of vascular surgery , The Second Affiliated Hospital of Nanchang University , Nanchang , People's Republic of China.
b Queen Mary college of Nanchang University , Nanchang , People's Republic of China.
出版信息
Hematology. 2019 Dec;24(1):108-111. doi: 10.1080/10245332.2018.1526440. Epub 2018 Oct 10.
OBJECTIVE
To investigate the association between the polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene and the formation of lower extremities deep venous thrombosis, and to evaluate the etiology of deep venous thrombosis.
METHODS
Polymorphisms of the 677th site C/T in MTHFR gene for 101 patients with lower extremities deep venous thrombosis (DVT group) and 120 healthy subjects (control group) were detected by polymerase chain reaction with sequence-specific primers. Genotype and allelic frequencies were compared between the two groups.
RESULTS
Genotype frequencies of CC, CT and TT in MTHFR C677 T were 41.58, 25.74 and 32.67% in DVT group, and 58.33, 23.33 and 18.33% in control group, respectively. There was a significant difference in TT genotype frequency between the two groups (P <0.05).
CONCLUSION
The frequency of MTHFR 677TT genotype may be correlated with the morbility of DVT.
目的
探讨亚甲基四氢叶酸还原酶（MTHFR）基因多态性与下肢深静脉血栓形成的关系，并评估深静脉血栓形成的病因。
方法
采用序列特异性引物聚合酶链反应检测101例下肢深静脉血栓患者（DVT组）和120例健康对照者（对照组）MTHFR基因第677位点C/T多态性。比较两组的基因型和等位基因频率。
结果
MTHFR C677T的CC型、CT型和TT型基因型频率在DVT组分别为41.58%、25.74%和32.67%，在对照组分别为58.33%、23.33%和18.33%。两组间TT基因型频率差异有统计学意义（P<0.05）。
结论
MTHFR 677TT基因型频率可能与DVT的发病有关。
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