Yadav Surekha, Sagar Nishant, Mallya Varuna, Mandal Sharmana, Khurana Nita, Gupta Sangeeta
Department of Pathology and Obstetrics and Gynaecology, Maulana Azad Medical College, New Delhi, India.
Maulana Azad Medical College, New Delhi, India.
Indian J Pathol Microbiol. 2018 Oct-Dec;61(4):614-616. doi: 10.4103/IJPM.IJPM_228_17.
Trophoblastic differentiation of endometrial carcinoma is extremely rare, till date 18 cases reports are there in the literature. A 68-year-old postmenopausal female presented with abnormal vaginal bleeding. Histopathologically, there were areas of serous carcinoma with trophoblastic differentiation (~90%). On immunohistochemistry, the trophoblastic component was positive for β-human chorionic gonadotropin (hCG), HPL and EMA. IHC confirmed the diagnosis of serous carcinoma with trophoblastic differentiation. The clinicopathological features of 18 previously reported cases of trophoblastic differentiation in the uterine tumor were analyzed in addition to the present case.
