School of Pharmacy , Fudan University , 826 Zhangheng Road , Pudong , Shanghai 201203 , China.
J Org Chem. 2018 Nov 2;83(21):13267-13275. doi: 10.1021/acs.joc.8b02073. Epub 2018 Oct 22.
A novel and practical copper-catalyzed strategy for intermolecular cyanosulfonylation and cyanotrifluoromethylation of unactivated alkenes in water-containing solvents is described. The methodology developed provides an efficient and convenient access to a variety of β-sulfonyl nitriles and β-trifluoromethyl nitriles, which would have wide applications in chemical and pharmaceutical industries.
一种新颖实用的铜催化策略，用于在含水溶剂中对未活化的烯烃进行分子间氰磺酰化和氰三氟甲基化反应。所开发的方法为各种β-磺酰基腈和β-三氟甲基腈的合成提供了一种高效便捷的途径，这些化合物在化学和制药工业中具有广泛的应用。
