Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic , Rochester, Minnesota.
Department of Neurology, Mayo Clinic , Rochester, Minnesota.
Physiology (Bethesda). 2018 Nov 1;33(6):374-383. doi: 10.1152/physiol.00024.2018.
Bilateral oophorectomy in premenopausal women is a unique condition causing the abrupt and premature loss of ovarian hormones, primarily estrogen. Bilateral oophorectomy causes an alteration of several fundamental aging processes at the cellular, tissue, organ, and system levels, leading to multimorbidity, frailty, and reduced survival. However, many questions remain unanswered.
在绝经前女性中进行双侧卵巢切除术是一种独特的情况,会导致卵巢激素(主要是雌激素)突然和过早丧失。双侧卵巢切除术导致细胞、组织、器官和系统水平的几个基本衰老过程发生改变,导致多种疾病、虚弱和生存时间缩短。然而,仍有许多问题尚未得到解答。