Vohra Fahim, Akram Zohaib, Bukhari Ishfaq A, Sheikh Saeed A, Riny Asma, Javed Fawad
Int J Periodontics Restorative Dent. 2018 Nov/Dec;38(6):e119-e126. doi: 10.11607/prd.3411.
The aim of the present study was to compare clinical periodontal parameters and salivary interleukin (IL)-1β and IL-6 levels in patients with different obesity levels. A total of 419 individuals with class I, II, and III obesity and nonobese with chronic periodontitis were included. Clinical periodontal parameters were recorded, and whole salivary IL-1β and IL-6 were quantified using enzyme-linked immunosorbent assay. Clinical parameters and salivary cytokine concentrations were analyzed using one-way analysis of variance. For multiple comparisons, Bonferroni post hoc adjustment test was used. Clinical periodontal parameters and salivary IL-1β and IL-6 levels were statistically significant in class II and class III obese as compared to class I obese patients (P < .01) but were comparable between class II and class III obese individuals. These findings should be interpreted with caution due to the inclusion of hyperglycemic patients.
本研究的目的是比较不同肥胖程度患者的临床牙周参数以及唾液白细胞介素（IL）-1β和IL-6水平。总共纳入了419例患有I、II和III级肥胖症以及非肥胖的慢性牙周炎患者。记录临床牙周参数，并使用酶联免疫吸附测定法定量全唾液中的IL-1β和IL-6。使用单因素方差分析对临床参数和唾液细胞因子浓度进行分析。对于多重比较，采用Bonferroni事后调整检验。与I级肥胖患者相比，II级和III级肥胖患者的临床牙周参数以及唾液IL-1β和IL-6水平具有统计学意义（P <.01），但II级和III级肥胖个体之间的这些参数具有可比性。由于纳入了高血糖患者，这些发现应谨慎解读。
