巴西中西部地区首例棘阿米巴角膜炎病例：诊断、寄生虫基因分型及疾病转归
The first Acanthamoeba keratitis case in the Midwest region of Brazil: diagnosis, genotyping of the parasite and disease outcome.
作者信息
Alves Daniella de Sousa Mendes Moreira, Gonçalves Gustavo Souza, Moraes Aline Silva, Alves Luciano Moreira, Carmo Neto José Rodrigues do, Hecht Mariana Machado, Nitz Nadjar, Gurgel-Gonçalves Rodrigo, Bernardes Geisa, Castro Ana Maria de, Chalita Maria Regina, Vinaud Marina Clare
机构信息
Laboratório de Estudos da Relação Parasito-Hospedeiro, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, GO, Brasil.
Departamento de Oftalmologia, Faculdade de Medicina, Universidade de Brasília, Brasília, DF, Brasil.
出版信息
Rev Soc Bras Med Trop. 2018 Sep-Oct;51(5):716-719. doi: 10.1590/0037-8682-0010-2018.
We report an Acanthamoeba keratitis case associated with the use of contact lens in a 28-year-old female from Brasília, Brazil. Samples from corneal scraping and contact lens case were used for culture establishment, PCR amplification, and partial sequencing (fragments of ~400kb) of small subunit rDNA; both culture and PCR were positive. The sequence analyses of the cornea and of isolates from the contact lens case showed similarity with the T4 genotype. To the best of our knowledge, this is the first report of T4 Acanthamoeba keratitis case from the Midwest region of Brazil.
我们报告了一例棘阿米巴角膜炎病例，该病例发生在一名来自巴西巴西利亚的28岁女性身上，与隐形眼镜的使用有关。取自角膜刮片和隐形眼镜盒的样本用于培养、PCR扩增以及小亚基核糖体DNA的部分测序（约400kb片段）；培养和PCR检测均呈阳性。对角膜和隐形眼镜盒分离株的序列分析显示与T4基因型相似。据我们所知，这是巴西中西部地区首例T4型棘阿米巴角膜炎病例报告。
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