Horiguchi J, Warren M K, Kufe D
Blood. 1987 Apr;69(4):1259-61.
The macrophage-specific colony-stimulating factor (CSF-1, M-CSF) regulates the survival, growth and differentiation of monocytes. We have recently demonstrated that phorbol ester induces expression of CSF-1 in human monocytes. These findings suggested that activated monocytes are capable of producing their own lineage-specific CSF. The present studies demonstrate that the granulocyte-macrophage colony-stimulating factor (GM-CSF) also induces CSF-1 transcripts in monocytes. Furthermore, we demonstrate that the detection of CSF-1 RNA in GM-CSF-treated monocytes is associated with synthesis of the CSF-1 gene product. The results thus suggest that GM-CSF may indirectly control specific monocyte functions through the regulation of CSF-1 production. These findings indicate another level of interaction between T cells and monocytes.
巨噬细胞特异性集落刺激因子（CSF-1，M-CSF）调节单核细胞的存活、生长和分化。我们最近证明佛波酯可诱导人单核细胞中CSF-1的表达。这些发现提示活化的单核细胞能够产生自身谱系特异性的CSF。目前的研究表明粒细胞-巨噬细胞集落刺激因子（GM-CSF）也可诱导单核细胞中CSF-1转录本的产生。此外，我们证明在GM-CSF处理的单核细胞中检测到CSF-1 RNA与CSF-1基因产物的合成相关。因此，结果提示GM-CSF可能通过调节CSF-1的产生间接控制特定的单核细胞功能。这些发现表明T细胞与单核细胞之间存在另一个相互作用层面。
