Vellenga E, Rambaldi A, Ernst T J, Ostapovicz D, Griffin J D
Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA 02115.
Blood. 1988 Jun;71(6):1529-32.
The macrophage and granulocyte colony-stimulating factors, M-CSF and G-CSF, act in vitro to induce proliferation and differentiation of monocyte and granulocyte progenitor cells, respectively. We show here that both of these CSFs can be produced by stimulated human blood monocytes, but the M-CSF and G-CSF genes are independently regulated. Recombinant human interleukin-3 (IL-3) and GM-CSF primarily induce expression of the M-CSF gene and secretion of M-CSF, whereas bacterial lipopolysaccharide primarily induces expression of the G-CSF gene and secretion of G-CSF. These results suggest that under different conditions of in vitro stimulation the monocyte secretes factors that could lead selectively to either granulocyte or monocyte production.
巨噬细胞集落刺激因子（M-CSF）和粒细胞集落刺激因子（G-CSF）在体外分别作用于单核细胞和粒细胞祖细胞，诱导其增殖和分化。我们在此表明，这两种集落刺激因子均可由受刺激的人血单核细胞产生，但M-CSF和G-CSF基因是独立调控的。重组人白细胞介素-3（IL-3）和粒细胞-巨噬细胞集落刺激因子（GM-CSF）主要诱导M-CSF基因的表达和M-CSF的分泌，而细菌脂多糖主要诱导G-CSF基因的表达和G-CSF的分泌。这些结果表明，在不同的体外刺激条件下，单核细胞分泌的因子可选择性地导致粒细胞或单核细胞的生成。
