Shanghai Key Laboratory for Molecular Imaging, Shanghai University of Medicine and Health Sciences, Pudong New Area, Shanghai, 201318, China.
Department of General Surgery, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai, 201800, China.
BMC Cancer. 2018 Oct 10;18(1):961. doi: 10.1186/s12885-018-4864-x.
Gastrointestinal symptoms occur in approximately 50% of patients with systemic lupus erythematous with low specificity. Although it is well established that colon cancer is one of the many gastrointestinal manifestations associated with systemic lupus erythematous, the diagnosis and treatment remains complex due to adrenal insufficiency symptoms.
A 43-year-old Chinese woman with a five-year history of systemic lupus erythematous was diagnosed with colon cancer based on imaging test. A radical bowel resection was performed successfully. To avoid serious complications during surgery, prednisone was replaced with methylprednisolone therefore avoiding adrenal insufficiency. The patient was subsequently treated with mFOLFOX6 chemotherapy and recovered well.
There is a lack of reports for treatment of colon cancer in patients with systemic lupus erythematous. This report provides an effective way to diagnose colon cancer in patients with systemic lupus erythematous and illustrates a successful therapy strategy for this complex medical condition.
胃肠道症状发生在大约 50%的系统性红斑狼疮患者中，但特异性较低。尽管已经确定结肠癌是与系统性红斑狼疮相关的许多胃肠道表现之一，但由于肾上腺功能不全的症状，其诊断和治疗仍然很复杂。
一名 43 岁的中国女性，患有五年系统性红斑狼疮病史，根据影像学检查诊断为结肠癌。成功进行了根治性肠切除术。为避免手术过程中的严重并发症，将泼尼松龙替换为甲基泼尼松龙，从而避免了肾上腺功能不全。随后，患者接受了 mFOLFOX6 化疗，恢复良好。
目前缺乏系统性红斑狼疮患者结肠癌治疗的报道。本报告提供了一种在系统性红斑狼疮患者中诊断结肠癌的有效方法，并为这种复杂的医疗状况说明了一种成功的治疗策略。
