Hayasaka S, Hara S, Mizuno K
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1977 Aug 8;203(2):139-44. doi: 10.1007/BF00413404.
Samples of serum from patients with ocular manifestation of Behçet's disease of various types were analyzed using acid phosphatase and beta-glucuronidase as lysosomal marker enzymes, in comparison to those from control patients with myopia, retinal detachment, and uveitis of unknown etiology. The lysosomal enzyme activities in Behçet's disease, especially in the attack phase, were found to be higher than those of the controls. In the sera of two patients with Behçet's disease, the activities in the attack phase were slightly higher than in the remission phase. It was suggested that the ocular symptoms in Behçet's disease might represent exacerbation better than other symptoms, in view of the high lysosomal enzyme activities in the attack phase, as classified by ocular symptoms alone.
使用酸性磷酸酶和β-葡萄糖醛酸酶作为溶酶体标记酶，对不同类型白塞病眼部表现患者的血清样本进行了分析，并与近视、视网膜脱离和病因不明的葡萄膜炎对照患者的样本进行了比较。发现白塞病患者的溶酶体酶活性，尤其是在发作期，高于对照组。在两名白塞病患者的血清中，发作期的活性略高于缓解期。鉴于仅按眼部症状分类时发作期溶酶体酶活性较高，提示白塞病的眼部症状可能比其他症状更能代表病情加重。
