一种用于生物成像和氧化应激下线粒体中 HBrO 生物传感的比率荧光探针。
A ratiometric fluorescent probe for bioimaging and biosensing of HBrO in mitochondria upon oxidative stress.
机构信息
Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Dongchuan Road 500, Shanghai 200241, P. R. China.
出版信息
Chem Commun (Camb). 2018 Oct 25;54(86):12198-12201. doi: 10.1039/c8cc07125j.
PMID:30306159
Abstract
A novel ratiometric fluorescent probe with high selectivity and sensitivity was designed and developed for bioimaging and biosensing of HBrO in mitochondria. Using this useful tool with low cytotoxicity and good biocompatibility, it was found that O2˙--induced oxidative stress triggered the burst of HBrO in mitochondria.
摘要
设计并开发了一种新型的比率型荧光探针，用于线粒体中 HBrO 的生物成像和生物传感，具有高选择性和灵敏度。使用这种具有低细胞毒性和良好生物相容性的有用工具，发现 O2˙--诱导的氧化应激引发了线粒体中 HBrO 的爆发。
Zotero 插件