更昔洛韦与阿昔洛韦治疗单纯疱疹性树枝状角膜炎的随机试验：一项多中心研究。
Randomised trial of ganciclovir and acyclovir in the treatment of herpes simplex dendritic keratitis: a multicentre study.
作者信息
Hoh H B, Hurley C, Claoue C, Viswalingham M, Easty D L, Goldschmidt P, Collum L M
机构信息
Bristol Eye Hospital.
出版信息
Br J Ophthalmol. 1996 Feb;80(2):140-3. doi: 10.1136/bjo.80.2.140.
Abstract
AIMS
This study was designed to assess the relative efficacy of topical ganciclovir 0.15% gel and acyclovir 3% ointment in the treatment of herpes simplex dendritic keratitis.
METHODS
Both treatment modalities were administered on a five times daily basis to patients suffering from herpes simplex keratitis. Patients were assigned randomly to one of the two treatment groups for the purpose of the trial. They were then examined on days 2, 7, 10, and 14 to assess the rate of healing of the dendritic ulceration.
RESULTS
There was no statistically significant difference detected in the rate of healing between the two treatment groups over the course of the trial.
CONCLUSIONS
Review of the relative efficacy of topical ganciclovir and acyclovir in the treatment of herpes simplex dendritic keratitis showed that both treatment modalities were equally effective in their ability to heal the viral induced corneal ulceration. There were no significant side effects or adverse effects reported for either treatment modality.
摘要
目的
本研究旨在评估0.15%更昔洛韦凝胶和3%阿昔洛韦软膏局部治疗单纯疱疹性树枝状角膜炎的相对疗效。
方法
两种治疗方式均每日5次给予单纯疱疹性角膜炎患者。为进行试验，患者被随机分配至两个治疗组之一。然后在第2、7、10和14天对他们进行检查，以评估树枝状溃疡的愈合速度。
结果
在试验过程中，两个治疗组之间的愈合速度没有检测到统计学上的显著差异。
结论
对局部使用更昔洛韦和阿昔洛韦治疗单纯疱疹性树枝状角膜炎的相对疗效进行回顾表明，两种治疗方式在治愈病毒引起的角膜溃疡方面同样有效。两种治疗方式均未报告有显著的副作用或不良反应。
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本文引用的文献
1
2
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Antimicrob Agents Chemother. 1993 Jul;37(7):1420-5. doi: 10.1128/AAC.37.7.1420.
3
Topical immunoglobulins for epithelial herpes simplex keratitis.用于上皮性单纯疱疹性角膜炎的局部用免疫球蛋白
Ophthalmologica. 1993;207(2):78-81. doi: 10.1159/000310409.
4
Ganciclovir for chronic active Epstein-Barr virus infection.
Lancet. 1993 Feb 27;341(8844):560-1. doi: 10.1016/0140-6736(93)90323-9.
5
6
Ganciclovir. An update of its therapeutic use in cytomegalovirus infection.更昔洛韦。其在巨细胞病毒感染中治疗应用的最新情况。
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7
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8
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Nouv Presse Med. 1981 Oct 10;10(36):2969-70, 2975.
9
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