Sundmacher R, Mattes A, Neumann-Haefelin D, Adolf G, Kruss B
Curr Eye Res. 1987 Jan;6(1):273-6. doi: 10.3109/02713688709020104.
Forty-five patients with virologically confirmed dendritic keratitis were treated in a randomized, double-blind controlled study with a basic therapy of trifluorothymidine (TFT) eye drops. In addition they received different human recombinant interferon (rHu IFN) eye drops. The following results were obtained for average healing times: TFT plus one drop daily of rHu IFN-alpha 2 arg (30 million iu/ml): 3.3 days, TFT plus rHu IFN-gamma (30 million iu/ml): 3.9 days, TFT plus a mixture of alpha plus gamma (0.3 million iu/ml each): 6.1 days, TFT plus a mixture of alpha plus gamma (1.5 million iu/ml each): 3.3 days. High-titer gamma interferon did not significantly differ from high-titer alpha interferon in the combination therapy of dendritic keratitis. A mixture of alpha plus gamma at a moderate titer (1.5 million iu/ml each) was as effective as a high-titer mono-preparation. Adding a low-titer interferon mixture gave no better therapeutic results than antiviral monotherapy. Thus it seems possible to save about 90% of interferon commonly used in the combination therapy of dendritic keratitis by applying a mixture of different suitable interferons instead of interferon monospecies.
在一项随机、双盲对照研究中，对45例经病毒学确诊的树枝状角膜炎患者采用三氟胸腺嘧啶核苷（TFT）滴眼液进行基础治疗。此外，他们还接受了不同的人重组干扰素（rHu IFN）滴眼液治疗。获得了以下平均愈合时间结果：TFT加每日一滴rHu IFN-α 2 arg（3000万国际单位/毫升）：3.3天，TFT加rHu IFN-γ（3000万国际单位/毫升）：3.9天，TFT加α加γ的混合物（各0.3万国际单位/毫升）：6.1天，TFT加α加γ的混合物（各150万国际单位/毫升）：3.3天。在树枝状角膜炎的联合治疗中，高滴度γ干扰素与高滴度α干扰素无显著差异。中等滴度（各150万国际单位/毫升）的α加γ混合物与高滴度单一制剂效果相同。添加低滴度干扰素混合物并不比抗病毒单一疗法产生更好的治疗效果。因此，通过应用不同合适干扰素的混合物而非单一干扰素种类，似乎有可能在树枝状角膜炎联合治疗中节省约90%常用的干扰素。
